Foretinib
Cat. No. :YN440081
CAS No. :849217-64-7
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order@ubiochem.com| Product Name: | Foretinib |
| CAS NO.: | 849217-64-7 |
| Chemical Name: | |
| Synonyms: | EXEL-2880,XL-880 |
| Molecular Weight: | 632.65 |
| Molecular Formula: | C₃₄H₃₄F₂N₄O₆ |
| SMILES: | O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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