Merestinib dihydrochloride
Cat. No. :YN440332
CAS No. :1206801-37-7
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order@ubiochem.com| Product Name: | Merestinib dihydrochloride |
| CAS NO.: | 1206801-37-7 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 625.45 |
| Molecular Formula: | C₃₀H₂₄Cl₂F₂N₆O₃ |
| SMILES: | [H]Cl.[H]Cl.O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailablec-Metinhibitor (Ki=2nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11nM), FLT3 (IC50=7nM), AXL (IC50=2nM), MERTK (IC50=10nM), TEK (IC50=63nM), ROS1, DDR1/2 (IC50=0.1/7nM) and MKNK1/2 (IC50=7nM). |
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| References: |
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