YN321729 Harmine

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but n...

YN350233 Rhoifolin 17306-46-6

Rhoifolin is a flavone glycoside isolated fromCitrus gr and is(L.) Osbeck leaves. Rhoifolin is beneficial for diabetic complications through enhanced adiponectin secretion, tyrosine phosphorylation ofinsulin receptor-β and glucose tra...

YN340120 Gandotinib 1229236-86-5

Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.

YN340247 Mutated EGFR-IN-1 1421372-66-8

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutatedEGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. More information can be fo...

YN340155 Mutant EGFR inhibitor 1421373-62-7

Mutant EGFR inhibitor is a potent and selective mutantEGFRinhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.

YN340046 AV-412 free base 451492-95-8

AV-412 free base (MP-412 free base) is an EGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN340183 WHI-P180 211555-08-7

WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR) , respectively.

YN340045 AV-412 451493-31-5

AV-412 (MP412) is anEGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN310343 Daphnetin 486-35-1

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activi...

YN340134 Mubritinib 366017-09-6

Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line. Phase 1.

YN321728 Harmine hydrochloride 343-27-1

Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value ...

YN321729 Harmine 442-51-3

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but n...

YN330135 RO2959 monohydrochloride 2309172-44-7

RO2959 monohydrochloride is a potent and selectiveCRAC channelinhibitor with an IC50 of 402nM. RO2959 monohydrochloride is a potent blocker ofstore operated calcium entry (SOCE)mediated byOrai1/Stim1 channelswith an IC5...

YN340153 Napabucasin 83280-65-3

Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor.

YN350251 Isoliquiritin apioside 120926-46-7

Isoliquiritin apioside, a component isolated fromGlycyrrhizae radix rhizome, significantly decreases PMA-induced increases inMMP9activities and suppresses PMA-induced activation ofMAPK and NF-κB. Isoliquiritin apioside...