YN270452 Tetramethylpyrazine 1124-11-4

Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

YN481900 Bromindione 1146-98-1

Bromindione is a potent, long-acting, in and ione-derived, oral anticoagulant compound.

YN481901 Chlorindione 1146-99-2

Chlophenadione is a potent anticoagulant compound.

YN480870 3,5-Diiodothyropropionic acid 1158-10-7

3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds tothyroid hormone receptor (TR), with Kaof 2.40 and 4.06 M-1for TRα1 and TRβ1, respectively.

YN330147 Trimethylamine N-oxide 1184-78-7

Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating theROS/NLRP3 inflammasome. Trimethylamine...

YN481781 Tranexamic acid 1197-18-8

Tranexamic Acid is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

YN321513 Xylometazoline hydrochloride 1218-35-5

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.

YN483136 Toringin 1329-10-8

Toringin, a bioflavonoid, is isolated from the bark of Docyniopsis tschonoski. Toringin progressively decreases not only the cis-effect of the exp and ed CTG repeats but cytotoxicity as well. Exposure to isosakuranetin, Toringin res...

YN270529 Ranaconitine 1360-76-5

Ranaconitine is a diterpene alkaloid isolated fromA. leucostomum, with cardiotoxicity.

YN360954 Guanfu base A 1394-48-5

Guanfu base A is an antiarrhythmic alkaloid isolated fromAconitum coreanum and is a potent noncompetitiveCYP2D6inhibitor, with a Ki of 1.20μM in human liver microsomes (HLMs) and a Ki of 0.37μM for the human recombinant f...

YN481926 Hydroquinidine 1435-55-8

Hydroquinidine is an antiarrhythmic agent.

YN321599 Vincamine 1617-90-9

Vincamine, an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.

YN372714 Dihomo-γ-linolenic acid 1783-84-2

Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E defic...

YN360476 Amiodarone 1951-25-3

Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1μM.

YN360762 Amiloride hydrochloride 2016-88-8

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).

YN482711 Quercetin 3,7-dimethyl ether 2068-02-2

Quercetin 3,7-dimethyl ether， isolated fromCroton schiedeanusSchlecht，has a NO/cGMP pathway-related profile, with increased vasorelaxant activity.

YN484487 3-(3,4-Dimethoxyphenyl)propan... 2107-70-2

3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies ...

YN480535 Menaquinone-7 2124-57-4

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reacti...

YN374153 2'-O-Methyladenosine 2140-79-6

2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities.

YN484212 Benzcyclane 2179-37-5

Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.