YN250203 TBAJ-587 2252316-16-6

TBAJ-587, a potentanti-tuberculosisagent, inhibitsM.tbstrain H37Rv growth withMIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibiti...

YN480860 Dooku1 2253744-54-4

Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca²⁺-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, ...

YN481053 BMS-986235 2253947-47-4

BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2(FPR2)agonist, with EC50s of 0.41nM and 3.4nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart fai...

YN350072 DMX-5804 2306178-56-1

DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 o...

YN330135 RO2959 monohydrochloride 2309172-44-7

RO2959 monohydrochloride is a potent and selectiveCRAC channelinhibitor with an IC50 of 402nM. RO2959 monohydrochloride is a potent blocker ofstore operated calcium entry (SOCE)mediated byOrai1/Stim1 channelswith an IC5...

YN360271 BI-749327 2361241-23-6

BI-749327 is a potent, high selectivity and orally bioavailableTRPC6antagonist, with IC50s of 13nM, 19nM and 15nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TR...

YN320371 RWJ-56110 dihydrochloride 2387505-58-8

RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor ofPAR-1activation and internalization (bindingIC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibi...

YN360383 AM12 2387510-84-9

AM12 inhibits Lanthanide-evokedTRPC5activity with an IC50 of 0.28μM.

YN370803 HMG499 2416941-68-7

HMG499 is a potent and selectiveHMG-CoA reductaseinhibitor with an IC50 of 0.41μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis.