YN321526 Pemirolast potassium 100299-08-9

Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

YN340069 (R)-Lisofylline 100324-81-0

(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is alysophosphatidic acid acyltransferaseinhibitor with an IC50 of 0.6 µM and interr...

YN321527 Desloratadine 100643-71-8

Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.

YN321000 Ebrotidine 100981-43-9

Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.5nM) with a potent antisecretory activity and evidenced gastroprotection.

YN373443 Microcystin-LR 101043-37-2

Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases(PP1 and PP2A), with IC50s of 1.7nM and 0.04nM, respectively.

YN370012 BW-A 78U 101155-02-6

BW-A78U, an adenine derivative PDE inhibitor, has anticonvulsant activity.

YN322009 Quinotolast sodium 101193-62-8

Quinotolast sodium in the concentration range of 1-100 μg/mL inhibitshistamine,LTC4 and PGD2release in a concentration-dependent manner.

YN321962 β-CGRP, human 101462-82-2

β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1nM and 300nM for CRLR...

YN250585 Lanoconazole 101530-10-3

Lanoconazole is a potent and orally active imidazoleantifungalagent, shows a broad spectrum of activity against fungi in vitro  and  in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethyl...

YN481670 Esonarimod 101973-77-7

Esonarimod is an antirheumatic drug.

YN372308 Zardaverine 101975-10-4

Zardaverine is a newly developed dual-selective PDE3/4 inhibitor with IC50 values of 0.5 uM and 0.8 uM respectively.

YN340084 Protosappanin A 102036-28-2

Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated fromCaesalpinia sappan L, suppressesJAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2...

YN483191 Epitheaflagallin 3-O-gallate 102067-92-5

Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococ...

YN330039 PGS-IN-1 102271-49-8

PGS-IN-1 is a potent inhibitor ofprostagl and in synthetase(PGS) with an IC50 of 0.28μM; also inhibits 5-lipoxygenasewith an IC50 of 1.05μM.

YN360631 Pantoprazole 102625-70-7

Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

YN483841 [D-p-Cl-Phe6,Leu17]-VIP 102805-45-8

[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist ofvasoactive intestinal peptide (VIP) receptor, with theIC50 of 125.8nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF recepto...

YN330569 Mulberroside A 102841-42-9

Mulberroside A is one of the main bioactive constituent in mulberry (Morus albaL.). Mulberroside A decreases the expressions ofTNF-α,IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and ...

YN330072 FPL 62064 103141-09-9

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostagl...

YN321444 Pranlukast 103177-37-3

Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.

YN330014 D-α-Hydroxyglutaric acid di... 103404-90-6

Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.