YN330166 Neocryptotanshinone 109664-02-0

Neocryptotanshinone, a fatty diterpenoids fromSalvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways.

YN360153 Zaldaride maleate 109826-27-9

Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor ofcalmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3nM. Z...

YN481664 Kifunensine 109944-15-2

Kifunensine, a potent and selective inhibitor ofclass I α-mannosidasesisolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

YN371090 Tautomycin 109946-35-2

Tautomycin, an antifungal antibiotic isolated from the bacteriumStreptomyces verticillatus, is a potent and specific inhibitor ofprotein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, wit...

YN270430 Taurodeoxycholic acid sodium ... 110026-03-4

Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid sodium hydrate is investigated for us...

YN482807 12-Epinapelline 110064-71-6

12-Epinapelline is a diterpene alkaloid isolated fromAconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors.

YN320048 Plerixafor 110078-46-1

Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively.

YN484236 D18024 110406-33-2

D18024 is a phthalazinonderivat antiallergic and antihistaminic activity.

YN482405 Epmedin C 110642-44-9

Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice. In vivo: Anesthetized with 0.4%pentobarbital sodium, mice of the ovariectomized group were conducted with Bilateral oophorectomy, while fat beside ovaries...

YN484216 KY-556 110816-78-9

KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.

YN372825 (rel)-Atorvastatin 110862-48-1

Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway.

YN480305 Aspartyl-alanyl-diketopiperaz... 110954-19-3

Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway im...

YN484211 HSR6071 111374-21-1

HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.

YN372182 Zileuton 111406-87-2

Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma.

YN483114 Proanthocyanidin A4 111466-29-6

Proanthocyanidin A4, isolated from the root ofE. sinica, is a polyphenol found in a variety of plants. Proanthocyanidin A4 possesses anti-inflammatory effects.

YN483277 Dehydroevodiamine hydrochlori... 111664-82-5

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

YN330062 MD2-IN-1 111797-22-9

MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.

YN320515 Misoprostol acid 112137-89-0

Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue ofprostagl and in E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal trac...

YN330665 Pam3CSK4 112208-00-1

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.

YN330666 Pam3CSK4 TFA 112208-01-2

Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.