YN372475 Leupeptin hemisulfate 103476-89-7

Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has n...

YN250551 Lansoprazole 103577-45-3

Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.

YN310355 Procyanidin A1 103883-03-0

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

YN482654 Tussilagone 104012-37-5

Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1. Tussilagone has anti-cancer activity, might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. Tussilag...

YN483144 11(α)-Methoxysaikosaponin F 104109-37-7

11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated fromBupleurum marginatumWall.ex DC(ZYCH) which is a promising therapeutic for liver fibrosis. 11(α)-Methoxysaikosaponin F has an IC50 of 387.7nM with viability...

YN321385 (±)-Bisoprolol hemifumarate 104344-23-2

Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.

YN280135 Typhaneoside 104472-68-6

Typhaneoside is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.

YN482967 Bayogenin 3-O-β-D-glucopyr... 104513-86-2

Bayogenin 3-O-β-D-glucopyranoside, a triterpenoid saponin isolated fromPolygala japonica, possesses anti-inflammatory activities.

YN410097 Caffeic acid phenethyl ester 104594-70-9

Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.

YN420013 CGS 15943 104615-18-1

CGS 15943 is an orally bioavailable non-xanthineAdenosine Receptorantagonist. ItsKifor human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50nM in transfected CHO cells, respectively..

YN251640 Ganoderol A 104700-97-2

Ganoderol A is a terpenoid extracted fromGanoderma lucidumwith antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA...

YN482357 Plantamajoside 104777-68-6

Plantamajoside is a phenylpropanoid glycoside isolated fromPlantago asiatica L.(Plantaginaceae). Plantamajoside has protective effects on LPS-induced acute lung injury (ALI) mice model. Plantamajoside has the potential for the...

YN320377 NF157 104869-26-3

NF157 is a highly selective nanomolarP2Y11antagonist with a pKi of 7.35. TheIC50s are 463nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively. NF157, significantly reduce...

YN321420 Tranilast sodium 104931-56-8

Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production ofprostagl and in D2(PGD2,IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodiu...

YN322073 CI-949 104961-19-5

CI-949 is an allergic mediator release inhibitor, which inhibitshistamine,leukotriene C4/D4(LTC4/LTD4), and thromboxane B2(TXB2)release with IC50s of 11.4μM, 0.5μM and 0.1μM, respectively.

YN330274 Tacrolimus 104987-11-3

Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

YN370191 Tibenelast sodium 105102-18-9

Tibenelast sodium is aphosphodiesteraseinhibitor.

YN480391 Apafant 105219-56-5

Apafant (WEB 2086), a potentplatelet-activating factor (PAF)antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9nM.

YN410109 Ginsenoside Rh3 105558-26-7

Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells inducesNrf2activation.

YN260028 Tr-PEG2-OH 105589-77-3

Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).