YN450086 Hydroxyfasudil 105628-72-6

Hydroxyfasudil is aROCKinhibitor, with IC50s of 0.73 and 0.72μM forROCK1 and ROCK2, respectively.

YN480022 TOK-8801 105963-46-0

TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator.

YN371379 Azadirachtin B 106500-25-8

Azadirachtin B is an limonoid isolated from seed kernels ofAzadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against theEpstein-...

YN330027 Ossirene 106566-58-9

AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.

YN372723 Adapalene 106685-40-9

Adapalene is a dual RAR and RXR agonist, used in the treatment of acne.

YN480332 GYY4137 106740-09-4

GYY4137 is a slow releasingH2S donorwith vasodilator and antihypertensive activity. GYY4137 also exhibits anti-inflammatory and anticancer activity .

YN270471 Demethylzeylasteral 107316-88-1

Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.

YN373967 Enazadrem 107361-33-1

Enazadrem is a5-lipoxygenaseinhibitor with antiinflammatory activities.

YN481854 Polaprezinc 107667-60-7

Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.

YN321146 Zafirlukast 107753-78-6

Zafirlukast is an oral leukotriene receptor antagonist (LTRA), used to prevent asthma symptoms.

YN330038 LY 178002 107889-32-7

LY 178002 is a potent inhibitor of5-lipoxygenase (5-LPO),phospholipase A2, with IC50 of 0.6μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibitio...

YN330144 RCGD423 108237-91-8

RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation.

YN483937 Moth Cytochrome C (MCC) ... 108273-68-3

Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes.

YN320208 AS-35 108427-72-1

AS-35 is an orally effective, potent and selective antagonist ofleukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8nM, 4nM and 3nM, respectively, and has antiallerg...

YN322050 FRG8701 108498-50-6

FRG-8701 is a newHistamine H2-receptorantagonist with an IC50 of ranging from 0.25 to 0.43μM.

YN361070 S3337 108499-48-5

S3337 is an H+, K+-ATPase inhibitor.

YN321404 Mizolastine 108612-45-9

Mizolastine is a histamine H1-receptor antagonist with IC50 of 47nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Mizolastine is a histamine H1-receptor antagonist with IC50...

YN483116 Purpureaside C 108648-07-3

Purpureaside C is a phenolic glycoside and has significant proinflammatory action.

YN321549 Epinastine hydrochloride 108929-04-0

Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

YN250564 Tacrolimus monohydrate 109581-93-3

Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds toFK506 binding protein (FKBP)to form a complex and inhibitscalcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcrip...