YN340187 AG-825 149092-50-2

AG-825 (Tyrphostin AG-825) is a selective and ATP-competitiveErbB2inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35μM. AG-825 displays anti-cancer activity . AG825 significantly accelerates apop...

YN371358 Talabostat 149682-77-9

Talabostat (Val-boroPro; PT100) is an orally active and nonselectivedipeptidyl peptidase IV (DPP-IV)inhibitor (IC50< 4nM;Ki= 0.18nM) and the first clinical inhibitor of fibroblast activation protein(FAP)(IC50= 560n...

YN481764 Tiludronate disodium 149845-07-8

Tiludronate disodium (Tiludronic Acid disodium) is a new bisphosphonate, which prevents postmenopausal bone loss. Tiludronate disodium (Tiludronic Acid disodium) presents antiresorptive and anti-inflammatory properties.

YN371359 Talabostat mesylate 150080-09-4

Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has an...

YN372840 Indinavir 150378-17-9

Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

YN330454 Balsalazide sodium hydrate 150399-21-6

Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine.

YN321445 Pranlukast hemihydrate 150821-03-7

Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptideleukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, a...

YN480785 7-O-Demethyl rapamycin 151519-50-5

7-O-Demethyl rapamycin, a derivative rapamycin (HY-10219), has antifungal activity and also immunosuppressant properties. 7-O-Demethyl rapamycin has useful tumor cell growth-inhibiting activity.

YN483920 LCMV gp33-41 151705-84-9

LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes.

YN320723 Montelukast sodium 151767-02-1

Montelukast selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1.

YN410132 Kinsenoside 151870-74-5

Kinsenoside is a main active component isolated from plants of the genusAnoectochilus, and exhibits many biological activities and pharmacological effects. Kinsenoside rescues the nucleus pulposus cells (NPCs) viability under oxid...

YN410151 Ac2-26 151988-33-9

Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in t...

YN484120 OVA (55-62) 151992-56-2

OVA 55-62 is a fragmented peptide of OVA (ovalbumin) antigen and can bind to the mouse MHC class I molecule, H2-Kb.

YN350023 SB 203580 152121-47-6

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.

YN482792 Buddlejasaponin IVb 152580-79-5

Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated fromClinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 %.

YN371741 TLK117 152684-53-2

TLK117, the active metabolite of TLK199, selective inhibitsGlutathione S-transferase P1–1 (GSTP1-1)with a Ki of 0.4μM for GSTP. TLK117 also competitively inhibitsglyoxalase Iwith a Ki of 0.56μM.

YN480309 Lysionotin 152743-19-6

Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.

YN270124 Z-Asp-CH2-DCB 153088-73-4

Z-Asp-CH2-DCB is an irreversible broad spectrumcaspaseinhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in sta...

YN320319 Asimadoline 153205-46-0

Asimadoline is a potentκ opioidreceptor agonist with IC50s of 5.6 and 1.2nM for guinea pig and human recombinant κ opioid receptor, respectively.

YN370394 Cilomilast 153259-65-5

Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.