Selumetinib
Cat. No. :YN350209
CAS No. :606143-52-6
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order@ubiochem.com| Product Name: | Selumetinib |
| CAS NO.: | 606143-52-6 |
| Chemical Name: | |
| Synonyms: | ARRY-142886 |
| Molecular Weight: | 457.68 |
| Molecular Formula: | C₁₇H₁₅BrClFN₄O₃ |
| SMILES: | O=C(C1=C(C(F)=C2N=CN(C2=C1)C)NC3=CC=C(C=C3Cl)Br)NOCCO |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Selumetinib (AZD6244) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Phase 3. |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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