YN360116 PSB-12062 55476-47-6

PSB-12062 is a potent and selectiveP2X4antagonist with an IC50 of 1.38μM for human P2X4.

YN482190 Acesulfame potassium 55589-62-3

Acesulfame potassium is a non-nutritive sweetener.

YN330573 Crocin II 55750-84-0

Crocin II is isolated from the fruit ofGardenia jasminoideswith antioxidant, anticancer, and antidepressant activity. Crocin II inhibits NO production with an IC50 value of 31.1μM. Crocin II suppresses the expressions of p...

YN380272 4-Hydroxyderricin 55912-03-3

4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selectiveMAO-B (Monoamine oxidase inhibitors)inhibitor with an IC50 of 3.43μM. 4-Hydroxyderricin also mildly inhibitsDBH (dopamine β-...

YN360352 Nicardipine 55985-32-5

Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.

YN360889 Afloqualone 56287-74-2

Afloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.

YN320019 DREADD agonist 21 56296-18-5

DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7nM).

YN380157 Fluoxetine hydrochloride 56296-78-7

Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.

YN484199 Octazamide 56391-55-0

Octazamide (ICI-US 457) is an analgesic drug.

YN310094 DCPLA-ME 56687-67-3

DCPLA-ME, the methyl ester form of DCPLA, is a potentPKCεactivator for use in the treatment of neurodegenerative diseases.

YN484250 Androst-4-ene-3,17-diol, dipr... 56699-31-1

and rost-4-ene-3,17-diol, dipropanoate, (3β,17β)- is the dipropanoate of 4- and rostenediol, a metabolite of testosterone.

YN360577 Etifoxine hydrochloride 56776-32-0

Etifoxine hydrochloride, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containingGABAAreceptors. Etifoxine hydrochloride reveals anxiolytic and anticonvulsant p...

YN482091 Eperisone Hydrochloride 56839-43-1

Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity.

YN360602 Flupirtine 56995-20-1

Flupirtine(D 9998) is a selective neuronal potassium channel opener that also hasnMDA receptor antagonist properties.

YN290030 Paprotrain 57046-73-8

Paprotrain is a cell-permeable inhibitor of thekinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35μM and a Ki of 3.36μM and shows a moderate inhibition activity onDYRK1Awith an IC50 of 5...

YN361005 Paxilline 57186-25-1

Paxilline is an indole alkaloid mycotoxin fromPenicillium paxilli, acts as a potentBK channelsinhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits thesarco/endoplasmic reticulum Ca2+ATPase (SE...

YN482889 Salsolinol-1-carboxylic acid 57256-34-5

Salsolinol-1-carboxylic acid is anendogenous alkaloidin the central nervous system (CNS).

YN321268 Setiptiline 57262-94-9

Setiptiline (Org-8282) is aserotonin receptorantagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine re...

YN380022 Calmidazolium chloride 57265-65-3

Calmidazolium chloride (R 24571) is acalmodulin (CaMK)antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35μM, respe...

YN320095 Methylergometrine maleate 57432-61-8

Methylergometrine maleate (Methylergonovine maleate) is an ergot alkaloid and an active metabolite of Methysergide with vasoconstrictive and uterotonic activity. Methylergometrine maleate is a potent, selective and orally active5-...