YN321040 cis-(Z)-Flupentixol dihydroc... 51529-01-2

Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.

YN321739 2'-O-Methylisoliquiritigenin 51828-10-5

2'-O-Methylisoliquiritigenin, isolated from theArachisspecies, up-regulates5-HT, NE, DA and GABApathways, but does not put a very significant effect on ne NE pathway.

YN321268 Setiptiline 57262-94-9

Setiptiline (Org-8282) is aserotonin receptorantagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine re...

YN320095 Methylergometrine maleate 57432-61-8

Methylergometrine maleate (Methylergonovine maleate) is an ergot alkaloid and an active metabolite of Methysergide with vasoconstrictive and uterotonic activity. Methylergometrine maleate is a potent, selective and orally active5-...

YN320708 BRL 54443 57477-39-1

BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.

YN320519 Iferanserin 58754-46-4

Iferanserin (S-MPEC) is a selective5-HT receptor(serotonin receptor) antagonist with an affinity for5-HT2Areceptor. Iferanserin has the potential for internal hemorrhoid disease treatment.

YN321749 Geissoschizine methyl ether 60314-89-8

Geissoschizine methyl ether, a major indole alkaloid found inUncariahook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent5-HT1Areceptoragonist.

YN320572 Oxatomide 60607-34-3

Oxatomide is a potent and orally active dualH1-histamine receptor and P2X7 receptorantagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current inhuman P2X7 receptors(IC...

YN321690 Clocapramine hydrochloride hy... 60789-62-0

Clocapramine hydrochloride hydrate is an antagonist of theD2 and 5-HT2Areceptors.

YN321456 (S)-Mirtazapine 61337-87-9

(S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective5-HT2receptorantagonist. (S)-Mirtazapine is me...

YN321457 (R)-Mirtazapine 61364-37-2

(R)-Mirtazapine ((R)-Org3770) is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a5-HT3receptorantagonist. (R)-Mirtazapine is mainly metaboliz...

YN321459 Urapidil hydrochloride 64887-14-5

Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.

YN320112 Asenapine 65576-45-6

Asenapine is an antagonist ofserotonin receptors(5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5-HT7),adrenoceptors(α1, α2A, α2B, α2C),dopamine receptors(D2, D3, D4) and histamine receptors(H1, H2), withpKis of 8.4-10.5, 8.9-9....

YN321080 RU 24969 66611-26-5

RU 24969 is a preferential5-HT1Bagonist, with a Ki of 0.38nM, but also displays appreciable affinity for the5-HT1Areceptor(Ki=2.5nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid ...

YN321081 RU 24969 hemisuccinate 66611-27-6

RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38nM, but also displays appreciable affinity for the5-HT1Areceptor(Ki=2.5nM), and has low affinity for other receptor sites in the brain. RU 24969 hemis...

YN320566 Arotinolol 68377-92-4

Arotinolol is a nonselectiveα/β-adrenergic receptorblocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radiolig and 125I-ICYP to5HT1B-serotonergic receptor sites. Arotinolol...

YN321315 Tianeptine 72797-41-2

Tianeptine is an antidepressant agent that act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors.

YN320198 Lidanserin 73725-85-6

Lidanserin (ZK-33839) acts as a5-HT2A and α1-adrenergic receptorantagonist.

YN320289 Ketanserin 74050-98-9

Ketanserin is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.

YN320342 Methiothepin mesylate 74611-28-2

Methiothepin mesylate is a potent and non-selective5-HT2receptorantagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and...