YN320965 Timapiprant 851723-84-7

Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known asCRTH2) antagonist. Timapiprant (OC000459) potently displaces [3H] PGD2 from human recombinant DP2(Ki=13nM), r...

YN321280 MK-0812 Succinate 851916-42-2

MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.

YN481673 MB-07344 852947-39-8

MB-07344 is a potentthyroid hormone receptor (TR)-βagonist with a Ki of 2.17nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys.

YN480450 MB-07811 852948-13-1

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targetedthyroid hormone receptor-βagonist. MB-07811 has cholesterol and triglycerides lowering activity.

YN360134 PG01 853138-65-5

PG01 is a potentCFTRCl-channel potentiator. PG01 can correct gating defects ofCFTRmutants, is effective on b>E193K,G970R and G551D(CFTR mutants) withKdvalues of 0.22μM, 0.45μM and 1.94μM, respectively. PG01...

YN270012 SecinH3 853625-60-2

SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.

YN440383 Indirubin Derivative E804 854171-35-0

Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor(IGF1R), with an IC50 of 0.65μM for IGF1R.

YN320964 NBI-74330 855527-92-3

NBI-74330 is a potent antagonist forCXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Kiof 1.5 and 3.2nM, respectively.

YN320432 L 888607 860033-06-3

L 888607 is a potent, and selectiveCRTH2(also known as DP2) agonist with a Ki of 0.8nM.

YN440010 NVP-BAW2881 861875-60-7

BAW2881 (NVP-BAW2881) is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor that potently inhibits VEGFR1-3 at 1.0-4.3 nanomolar (nM) concentrations and inhibits PDGFRβ, c-Kit, and...

YN320902 Anamorelin hydrochloride 861998-00-7

Anamorelin (RC-1291) hydrochloride is a potentghrelin receptoragonist withEC50value of 0.74nM in the FLIPR assay.

YN320298 PF-00446687 862281-92-3

PF-00446687 is a potent, selectivemelanocortin-4 receptor(MC4R) agonist withEC50of 12 ± 1nM. Pf-446687 is brain penetrant.

YN322020 MK-0249 862309-06-6

MK-0249 is a potenthistamine H3 receptorantagonist, with Kiof 1.7nM for human H3.

YN320269 S 38093 862896-30-8

S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.

YN320903 Azilsartan medoxomil 863031-21-4

Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.

YN321069 Setipiprant 866460-33-5

Setipiprant(ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.

YN440050 Linsitinib 867160-71-2

Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Pha...

YN330668 TLQP-21 869988-94-3

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potentG-protein-coupled receptor complement-3a receptor 1 (C3aR1)agonist (EC50: mouse TLQP-21=10.3μM; human TLQP-21=68.8μM). T...

YN320350 Almorexant 871224-64-5

Almorexant (ACT 078573) is a potent  and  competitive dualorexin 1 receptor(OX1)/orexin 2 receptor(OX2) antagonist with Ki values of 1.3  and  0.17nM, respectively.

YN321092 Fevipiprant 872365-14-5

Fevipiprant (QAW039; NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44nM for inhibiti...