YN320927 Cenicriviroc Mesylate 497223-28-6

Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.

YN480459 TR antagonist 1 500794-88-7

TR antagonist 1 is a high-affinitythyroid hormone receptor (TR)antagonist with IC50s of 36 and 22nM for TRα and TRβ, respectively.

YN320846 Vilanterol 503068-34-6

Vilanterol (GW642444) is a long-actingβ2-adrenoceptor(β2-AR) agonist with 24 h activity. ThepEC50s for β2-AR,β1-AR and β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

YN320847 Vilanterol trifenatate 503070-58-4

Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.

YN321273 CCR2-RA-[R] 512177-83-2

CCR2-RA-[R] is an allosteric antagonist of theC-C chemokine receptor type 2 (CCR2)with an IC50 of 103nM.

YN320315 JNJ-10229570 524923-88-4

JNJ-10229570 is an antagonist ofmelanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gl and differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding...

YN321580 Fexofenadine D6 548783-71-7

Fexofenadine D6 (MDL-16455 D6) is deuterium labeled is Fexofenadine, which is an antihistamine pharmaceutical agent.

YN320904 Rolapitant 552292-08-7

Rolapitant is a potent, selective and orally active neurokinin NK1 receptor antagonist.

YN320832 Macitentan (n-butyl analogue) 556797-16-1

Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelinETA and ETB receptorantagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and ...

YN321274 Mavorixafor 558447-26-0

Mavorixafor (AMD-070) is a potent, selective and orally availableCXCR4antagonist, with an IC50 value of 13nM against CXCR4125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in M...

YN322016 AZD2098 566203-88-1

AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.

YN321278 Laropiprant 571170-77-9

Laropiprant is a potent, selectiveDP receptorantagonist with Ki values of 0.57nM and 2.95nM for DP receptor and TP Receptor, respectively.

YN321125 Vicriviroc maleate 599179-03-0

Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist ofCCR5, with a Ki of 2.5nM, and also inhibits HIV-1 in PBMC cells, withIC90s of 3.3n...

YN480440 MK-0773 606101-58-0

MK-0773 is aselective and rogen receptor modulators (SARMs)that binds to AR with an IC50 of 6.6nM.

YN322021 SUN 1334H 607736-84-5

SUN 1334H is a potent, orally active, highly selectiveH1 receptorantagonist, with Kiof 9.7nM.

YN320915 Tasimelteon 609799-22-6

Tasimelteon is a melatonin MT1 and MT2 receptor agonist.

YN321086 Tradipitant 622370-35-8

Tradipitant (VLY-686) is aneurokinin-1(NK-1) antagonist.

YN480732 BMS-564929 627530-84-1

BMS-564929 is an and rogen receptor(AR) agonist, binds to and rogen receptor (AR) with a Ki of 2.11±0.16nM.

YN440159 AGL-2263 638213-98-6

AGL-2263 is aninsulin receptor and insulin-like growth factor (IGF) receptorinhibitor.

YN371335 Homo Sildenafil 642928-07-2

Homo Sildenafil, an analog of Sildenafil, acts as aphosphodiesteraseinhibitor.