Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN320512 Exicorilant 1781244-77-6
Exicorilant (CORT 125281) is a selective and oral activeglucocorticoid receptor (GR)antagonist, with aKivalue of 7nM. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia.
YN321111 Alcaftadine-D3 1794775-80-6
Alcaftadine-D3 (R89674-D3) is a deuterium labeled Alcaftadine. Alcaftadine (HY-17039) is a H1 histamine receptor antagonist.
YN321214 Orexin 2 Receptor Agonist 1796565-52-0
Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.
YN320675 Pimozide D4 1803193-57-8
Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide. Pimozide is adopamine receptorantagonist, with Kis of 1.4nM, 2.5nM and 588nM fordopamine D2,D3 and D1 receptors, respectively, and also has affinity atα1-adrenoceptor...
ONC212, a fluorinated-ONC201 analogue, is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity.
YN484117 Atrial Natriuretic Peptide ... 1815618-06-4
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for...
SBI-553 is a potent and brain penetrantNTR1allosteric modulator, with an EC50 of 0.34μM.
YN320097 CXCR2-IN-1 1873376-49-8
CXCR2-IN-1 is a central nervous system penetrantCXCR2antagonists with apIC50 of 9.3.
YN320608 Terlipressin acetate 1884420-36-3
Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selectivevasopressin V1 receptoragonist that reduces the splanchnic blood flow and portal pressure and controls acute ...
AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model ...
PTI-428 is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier.
YN321400 Ivabradine D6 hydrochloride 2070009-63-9
Ivabradine D6 hydrochloride is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new Ifinhibitor with IC50 of 2.9μM, and used as a pure heart rate lowering agent.
YN321531 Hydroxyzine D4 2070014-84-3
Hydroxyzine D4 is deuterium labeled Hydroxyzine. Hydroxyzine is a heterocyclichistamine H1-receptorantagonist. Hydroxyzine has anticholinergic, anxiolytic and analgesic properties.
YN321239 Adriforant hydrochloride 2096455-90-0
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novelhistamine H4 receptorantagonist binding affinity (Ki=2.4nM) and is also a functional (Ki=1.56nM) antagonist.
YN320677 TSHR antagonist S37a 2143452-20-2
TSHR antagonist S37a is a highly selectivethyrotropin receptor (TSHR)antagonist, with potential for the treatment of Graves' orbitopathy.
YN320676 TSHR antagonist S37b 2143452-22-4
TSHR antagonist S37b is an enantiomer of TSHR antagonist S37a (HY-129995A), shows only a minor effect forTSHRinhibition. TSHR antagonist S37b can be used for the research of thyroid function.
LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in a...
YN320349 CXCR7 modulator 1 2231812-31-8
CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybridCXCR7modulator, with a Ki of 9nM.
YN321275 Mavorixafor trihydrochloride 2309699-17-8
Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally availableCXCR4antagonist, with an IC50 value of 13nM against CXCR4125I-SDF binding, and also inhibits the replication of T-tro...
YN340254 AZ7550 hydrochloride 2309762-40-9
AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity ofIGF1Rwith an IC50 of 1.6μM.
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