Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN360398 Ivacaftor 873054-44-5
Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.
RF9 is a potent and selectiveNeuropeptide FF receptorantagonist, with Ki values of 58 and 75nM forhNPFF1R and hNPFF2R, respectively.
AZD-5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.
YN322065 CCR3 antagonist 1 879399-82-3
CCR3 antagonist 1 is a potent antagonist ofCCR3, used for the research of immunologic and inflammatory diseases.
YN483137 S-Dihydrodaidzein 879559-75-8
S-Dihydrodaidzein is the (S)-enantiomer of dihydrodaidzein which is one of the most prominent dietary phytoestrogens.
YN360002 Vonoprazan 881681-00-1
Vonoprazan (TAK-438 free base) is an orally activepotassium-competitive acid blockerwhich inhibits H+, K+-ATPase activity with an IC50 of 19nM.
YN360532 Vonoprazan Fumarate 881681-01-2
Vonoprazan Fumarate (TAK-438) is an orally activepotassium-competitive acid blockerwhich inhibits H+, K+-ATPase activity with an IC50 of 19nM.
YN320924 Verucerfont 885220-61-1
Verucerfont is acorticotropin-releasing factor receptor 1(CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.
YN321025 Vercirnon sodium 886214-18-2
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist ofCCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4...
YN320922 (S)-Mapracorat 887375-15-7
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
YN320921 Mapracorat 887375-26-0
Mapracorat is a novel non-steroidal selectiveglucocorticoid receptoragonist.
YN320991 INCB 3284 887401-92-5
INCB 3284 is a potent, selective and orally bioavailable humanCCR2antagonist, inhibiting monocyte chemoattractant protein-1 binding tohCCR2, with an IC50 of 3.7nM. INCB 3284 can be used in the research of acute liver fail...
MSX-122 is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).
XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN...
YN320941 Cligosiban 900510-03-4
Cligosiban (PF-3274167), a high oral bioavailability and good brain-penetrant non-peptideoxytocin receptorantagonist, shows a high-affinity (Ki=9.5nM) and an excellent selectivity versus the vasopressin receptors with almost no aff...
YN320562 Pitolisant hydrochloride 903576-44-3
Pitolisant acts as a high-affinity competitive antagonist (Ki=0.16 nM) and as an inverse agonist (EC50=1.5 nM) at the human histamine H3 receptor subtype.
YN320013 SCH 546738 906805-42-3
SCH 546738 is a potent, orally active and non-competitiveCXCR3antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4nM in multiple experiments.
AZD8797 is an allosteric non-competitive and orally active antagonist of the humanCX3CR1receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800nM, respectively.
YN320943 ELN-441958 913064-47-8
ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist lig and [3H]DAKD to IMR-90 cells with Ki of 0.26nM. ELN-441958 is highly selective for B1 over B2 receptors, and >500/ ...
YN320352 Almorexant hydrochloride 913358-93-7
Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.
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