YN321096 GW627368 439288-66-1

GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoidEP4receptor with additional humanTPreceptor affinity, with pKi values. of 7.0 and 6.8 for human prostanoid EP4 and TP receptors re...

YN320831 Macitentan 441798-33-0

Macitentan is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM.

YN320207 BMS CCR2 22 445479-97-0

BMS CCR2 22 is a potent, specific and high affinityCC-type chemokine receptor 2 (CCR2)antagonist with excellent binding affinity (bindingIC50 of 5.1nM) and potent functional antagonism (calcium fluxIC50 of 18nM and ch...

YN320741 JNJ-7777120 459168-41-3

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

YN320546 Pexacerfont 459856-18-9

Pexacerfont is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6nM for human CRF1receptor.

YN320559 ABT-239 460746-46-7

ABT-239 is a novel, highly efficacious, non-imidazole class ofH3Rantagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

YN321138 Aplaviroc 461443-59-4

Aplaviroc (AK 602), a SDP derivative, is aCCR5antagonist, with IC50s of 0.1-0.4nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.

YN320942 SSR240612 464930-42-5

SSR240612 is a potent, and orally active specific non-peptidebradykinin B1 receptorantagonist, with Kis of 0.48nM and 0.73nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 4...

YN440073 BMS-536924 468740-43-4

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.

YN320962 AMG 487 473719-41-4

AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively...

YN320210 Navarixin 473727-83-2

SCH-527123 is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.

YN320003 SCH 563705 473728-58-4

SCH 563705 is a potent and orally availableCXCR2 and CXCR1antagonist, with IC50s of 1.3nM, 7.3nM and Kis of 1 and 3nM, respectively.

YN321314 MRE-269 475085-57-5

MRE-269 is an active metabolite of selexipag, and acts as a selectiveIP receptoragonist.

YN320923 Selexipag 475086-01-2

Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (...

YN440068 NVP-ADW742 475488-23-4

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

YN440405 NVP-AEW541 475489-16-8

NVP-AEW541 is a potent inhibitor ofIGF-1Rwith IC50 of 0.15μM, also inhibitsInsR, with IC50 of 0.14μM.

YN320004 AT2 receptor agonist C21 477775-14-7

AT2 receptor agonist C21 is a druglike selectiveangiotensin II AT2 receptoragonist with Ki values of 0.4nM and >10µM for the AT2 receptor and AT1 receptor, respectively.

YN320391 SB-674042 483313-22-0

SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76nM); exhibits 100-fold selectivity for OX1 over OX2 receptors. SB-674042 has no effect at serotonergic, dopaminergic, adrenergic or puri...

YN484197 Testosterone tridecanoate 488836-58-4

Testosterone tridecanoate is a prodrug of testosterone. Testosterone is the primary male sex hormone and an anabolic steroid.

YN320926 Cenicriviroc 497223-25-3

Cenicriviroc (CVC, TAK-652, TBR-652) is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective a...