YN440055 BMS-754807 1001350-96-4

BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PK...

YN320271 MK-2894 1006036-87-8

MK-2894 is a potent, selective, orally active and high affinity (Ki=0.56nM) full antagonist againstE prostanoid receptor 4 (EP4 receptor)(IC50=2.5nM). MK-2894 possesses potent anti-inflammatory activity in animal models of pai...

YN320272 MK-2894 sodium salt 1006036-88-9

MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56nM) full antagonist againstE prostanoid receptor 4 (EP4 receptor)(IC50=2.5nM). MK-2894 sodium salt possesses potent anti-inflammatory activity...

YN321019 Cort108297 1018679-79-2

Cort108297 is a specificglucocorticoid receptor(GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45nM.

YN440162 Insulin levels modulator 1019254-94-4

Insulin levels modulator could be used to treat diabetes.

YN321656 Lorglumide sodium salt 1021868-76-7

Lorglumide sodium salt (CR-1409 sodium salt) is a potentcholecystokinin(CCK)receptorantagonist.

YN320145 VUF10460 1028327-66-3

VUF10460 is a non-imidazole histamineH4receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

YN321158 Losartan D4 1030937-27-9

Losartan D4 (DuP-753 D4) is the deuterium labeled Losartan. Losartan is anangiotensin II receptorantagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20nM.

YN440335 Ceritinib 1032900-25-6

Ceritinib (LDK378) is potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Phase 3.

YN320354 AZD5423 1034148-04-3

AZD5423 is an inhaled, potent, selective, and non-steroidalglucocorticoid receptor (GR)modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.

YN320468 AZD2906 1034148-15-6

AZD2906 is a selectiveglucocorticoid receptor (GR)agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5nM at GR in human, rat PBMC and human, r...

YN320421 PF-03654746 Tosylate 1039399-17-1

PF-03654746 Tosylate is a potent and selectivehistamine H3 receptorantagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms. PF-03654746 Tosylate has potential for treatment of human c...

YN321084 Fosdagrocorat 1044535-58-1

Fosdagrocorat (PF-04171327) is a dissociatedglucocorticoid receptoragonist.

YN320107 JNJ-39758979 1046447-90-8

JNJ-39758979 is a selective, orally active, and high-affinityhistamine H4receptorantagonist with Kis of 12.5, 5.3, and 25nM for human, mouse, and monkey histamine H4receptor, respectively. JNJ-39758979 functionally antagoniz...

YN321405 Mizolastine dihydrochloride 1056596-82-7

Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Mizolastine is a histamine H1-receptor antago...

YN320417 SNT-207707 1064662-40-3

SNT-207707 is a selective, potent and orally activemelanocortin MC-4receptor antagonist with an IC50 of 8nM (binding) and 5nM (function) on the MC-4 receptor.

YN321200 PF-04418948 1078166-57-0

PF-04418948 is a potent and selective prostaglandin EP? receptor antagonist with IC50 of 16 nM. Phase 1.

YN321816 AZP-531 1088543-62-7

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

YN320602 LY2510924 1088715-84-7

LY2510924 is a potent and selectiveCXCR4antagonist that blocks SDF-1 binding to CXCR4 with an IC50 of 0.079nM.

YN321012 Filorexant 1088991-73-4

Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3nM in binding).