YN250264 Thiophene-2 420089-51-6

Thiophene-2 (TP2) is a specificpolyketide synthase 13 (Pks13)inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active againstMycobacterium tuberculosiswith a MI...

YN250539 SJ000025081 421571-66-6

SJ000025081 is a dihydropyridine and acts as a potentantimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected withP. yoelii.

YN374371 PfDHODH-IN-2 425629-94-3

PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potentPlasmodium falciparumdihydroorotate dehydrogenase (PfDHODH)inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent an...

YN250081 RN-18 431980-38-0

RN-18 is a HIV-1 viral infectivity factor (HIV-1 Vif) inhibitor with an IC50 of 6μM in nonpermissive H9 cells.

YN250351 Filastatin 431996-53-1

Filastatin is a long-lasting inhibitor ofC and ida albicansfilamentation. Filastatin inhibits adhesion by multiple pathogenicC and idaspecies with an IC50 of ~3μM in the GFP-based adhesion assay. Filastatin inhibitsfungaladhesio...

YN250129 LB80317 441785-24-6

LB80317 is an active metabolite of LB80380 and suppresses theDNA synthesisofHBVwith an EC50 of 0.5μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment.

YN250802 Besifovir 441785-25-7

Besifovir is novel and potent acyclic nucleotide phosphonate used to treat hepatitis B virus (HBV) infection.

YN250470 Anguizole 442666-98-0

Anguizole is a small molecule inhibitor of HCV replication and alters NS4B's subcellular distribution.

YN250217 S119-8 443639-96-1

S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatit...

YN250087 MK-0608 443642-29-3

MK-0608 is a potent and orally bioavailable inhibitor ofHCV replicationin vitro with an EC50 of 0.3μM (EC90=1.3μM) in the subgenomic-replicon assay.

YN250589 Brincidofovir 444805-28-1

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV...

YN251858 Human β-defensin-1 452274-53-2

Human β-defensin-1 (HβD-1) is a cysteine-rich cationicskin-antimicrobial peptide (SAP)produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial...

YN250261 IR415 452967-14-5

IR415 is a potentanti-HBV agent and inhibitsHBV replicationby blocking the HBx activity. IR415 selectively interacts withHBx(Kd=2nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx ...

YN321138 Aplaviroc 461443-59-4

Aplaviroc (AK 602), a SDP derivative, is aCCR5antagonist, with IC50s of 0.1-0.4nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.

YN250383 Sordarin sodium 463356-00-5

Sordarin is a potent diphthamide-dependenteEF2inhibitor withantifungalproperties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifi...

YN250583 Lersivirine 473921-12-9

Lersivirine (UK-453061) is potent and selectivenon-nucleoside reverse transcriptioninhibitor (NNRTI;IC50=119nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity ...

YN250079 Inarigivir 475650-36-3

Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liverHBVDNA in transgenic mice expressing hepatitis B virus.

YN250003 Bay 41-4109 (less active enan... 476617-51-3

Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53nM.

YN250106 R-1479 478182-28-4

R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) ofHCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC50=1.28μM) .

YN250543 A2ti-2 482646-13-9

A2ti-2 is a selective and low-affinityannexin A2/S100A10 heterotetramer (A2t)inhibitor with an IC50 of 230μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents hu...