YN251426 Sofosbuvir impurity I 2164516-85-0

Sofosbuvir impurity I, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor ofHCVRNA replication, demonstrates potent anti-hepatitis C virus activity.

YN250467 PK150 2165324-62-7

PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitiveS. aureus(MSSA), Met...

YN371044 LysRs-IN-2 2170696-76-9

LysRs-IN-2 is alysyl-tRNA synthetase (KRS)inhibitor with IC50s of 0.015μM and 0.13μM forPlasmodium falciparumlysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvumlysyl-tRNA synthetase (CpKRS), respectiv...

YN250805 Ribocil-C (R enantiomer) 2177266-81-6

Ribocil-C R enantiomer is the R enantiomer of Ribocil-C. Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

YN250207 Lenacapavir 2189684-44-2

Lenacapavir (GS-6207) is aHIV-1 capsidinhibitor. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells. Lenacapavir displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from ...

YN250192 Antifungal agent 2 2211060-61-4

Antifungal agent 2 is a broad-spectrumfungalinhibitor which inhibits growth of pertinent species ofC and ida, Cryptococcus, and Aspergillusat a concentration as low as 0.5 μg/mL.

YN250137 Polymyxin B nonapeptide TF... 2220175-42-6

Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its abil...

YN250760 Dalbavancin hydrochloride 2227366-51-8

Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity againstGram-positive bacteria. Dalbavancin hydrochloride inhibitsStaphylococcus aureus and Bacillus...

YN370601 Grp94 Inhibitor-1 2234897-35-7

Grp94 Inhibitor-1 is a potent, selectiveGrp94inhibitor with an IC50 value of 2nM, and over 1000-fold selectivity to Grp94 against Hsp90α.

YN250234 AWZ1066S 2239272-16-1

AWZ1066S is a highly specific anti-Wolbachiadrug c and idate for a short-course treatment of filariasis, with an EC50 of 2.5nM in cell assay.

YN250362 G907 2244035-16-1

G907 is a selective small-molecule antagonist ofATP-binding cassette (ABC) transporter, MsbA. It inhibits purifiedE. coliMsbA in amphipols with an IC50 of 18nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-boun...

YN250180 Taniborbactam hydrochloride 2244235-49-0

Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrumβ-lactamaseinhibitor with IC50s of 8-530nM. Taniborbactam hydrochloride hasIC50s of 30nM, 32nM, 42nM, 2...

YN371556 PF429242 dihydrochloride 2248666-66-0

PF429242 dihydrochloride is a reversible and competitiveSREBPsite 1 protease (S1P) inhibitor with an IC50 of 175nM.

YN250203 TBAJ-587 2252316-16-6

TBAJ-587, a potentanti-tuberculosisagent, inhibitsM.tbstrain H37Rv growth withMIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibiti...

YN250219 MBX-4132 2286411-30-9

MBX-4132, a member of a chemical class called oxadiazoles that inhibit trans translation by binding to the bacterial ribosome.

YN250233 BA-53038B 2306195-65-1

BA-53038B is aHBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly in a distinct manner, with an EC50 value of 3.32μM.

YN321275 Mavorixafor trihydrochloride 2309699-17-8

Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally availableCXCR4antagonist, with an IC50 value of 13nM against CXCR4125I-SDF binding, and also inhibits the replication of T-tro...

YN250054 ST-193 hydrochloride 2320274-72-2

ST-193 hydrochloride is a potent broad-spectrumarenavirusinhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1nM, respectively.

YN250506 EIDD-2801 2349386-89-4

EIDD-2801 is an orally bioavailable prodrug of the ribonucleoside analog β-d-N⁴-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, <...

YN250202 CWHM-1008 2362539-97-5

CWHM-1008 is a potent and orally activeantimalarialagent, withEC50values of 46 and 21nM against drug-sensitivePlasmodium falciparum3D7 and drug-resistant Dd2 strains, respectively.