YN320314 GW 766994 408303-43-5

GW 766994 (GW 994) is an orally active and specificchemokine receptor-3 (CCR3)antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research.

YN484128 TET 830 modified/T-helper ... 410527-75-2

TET 830 modified/T-helper epitope from tetanus toxoid is a modified T-helper epitope from tetanus toxoid. TET 830 modified/T-helper epitope from tetanus toxoid induces T-cells responses and is used as a helper peptide in vaccina...

YN370222 Rilapladib 412950-08-4

Rilapladib (SB 659032) is a selectiveLp-PLA2(lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist.

YN483853 BAM(8-22) 412961-36-5

BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.

YN310065 Sotrastaurin 425637-18-9

Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay inactive to PKCζ. Phase 2.

YN410015 TRAF-STOP inhibitor 68... 433249-94-6

TRAF-STOP inhibitor 6877002, is a selective inhibitor ofCD40-TRAF6interaction, compound VII, shows inhibition ofNF-κBactivation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP 6877002 prevent...

YN481205 Desfluoro-atorvastatin 433289-84-0

Desfluoro-atorvastatin is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.

YN330176 GW274150 phosphate 438542-15-5

GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of humaninducible nitric oxide synthase (iNOS)(IC50=2.19μM;Kd=40nM) and ratiNOS(ED50=1.15μM). GW274150 phosphate displays le...

YN321096 GW627368 439288-66-1

GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoidEP4receptor with additional humanTPreceptor affinity, with pKi values. of 7.0 and 6.8 for human prostanoid EP4 and TP receptors re...

YN440138 BMS-509744 439575-02-7

BMS-509744 is a potent, selective and ATP competitiveItkinhibitor with an IC50 of 19nM.

YN482965 Isoscabertopin 439923-16-7

Isoscabertopin is a sesquiterpene lactone isolated fromElephantopus scaber L and showsanti-tumoractivities.

YN300041 CK-636 442632-72-6

CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.

YN270115 TNF-α-IN-1 444287-49-4

TNF-α-IN-1 is aTNF-αinhibitor extracted from patent US20030096841A1, compound example I-7.

YN350037 Dilmapimod 444606-18-2

Dilmapimod (SB-681323) is a potentp38 MAPKinhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

YN320207 BMS CCR2 22 445479-97-0

BMS CCR2 22 is a potent, specific and high affinityCC-type chemokine receptor 2 (CCR2)antagonist with excellent binding affinity (bindingIC50 of 5.1nM) and potent functional antagonism (calcium fluxIC50 of 18nM and ch...

YN330368 ITE 448906-42-1

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly toAHR, with a Ki of 3nM. ITE also has immunosuppressive activity.

YN350039 Pamapimod 449811-01-2

Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activ...

YN440153 TIE-2/VEGFR-2 kinase-I... 453590-24-4

TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and /or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated w...

YN300056 Zaurategrast ethyl ester 455264-30-9

Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758 , is aα4β1/α4β7integrin antagonist used for the treatment of inflammatory and autoimmune disorders.

YN300055 Zaurategrast 455264-31-0

Zaurategrast (CT7758) is a potent and oral-effectiveα4-integrininhibitor.