YN410121 Ginsenoside Rk3 364779-15-7

Ginsenoside Rk3 is present in the rootsPanax notoginsengherbs. Ginsenoside Rk3 significantly inhibits TNF-α-inducedNF-κBtranscriptional activity, with an IC50 of 14.24±1.30μM in HepG2 cells.

YN370335 Arimoclomol citrate 368860-21-3

Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP). Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded as...

YN310072 CAY10602 374922-43-7

CAY10602 is aSIRT1activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells.

YN320679 Maraviroc 376348-65-1

Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively.

YN251866 rCRAMP (rat) 376364-38-4

rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system ...

YN481615 BVT 2733 376640-41-4

BVT 2733, a new small molecule, is a non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).

YN373968 Ecopladib 381683-92-7

Ecopladib is a sub-micromolar inhibitor of cytosolicphospholipase A2α (cPLA2α), with IC50s of 0.15μM and 0.11μM in the GLU micelle and rat whole blood assays, respectively.

YN330371 Naproxen etemesil 385800-16-8

Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is aCOX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15μM, respecti...

YN330139 Imrecoxib 395683-14-4

Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18nM, it also inhibits COX1- activity with an IC50 value of 115nM. Imrecoxib (BAP-909) has anti-inflammatory effect.

YN320948 Fluticasone furoate 397864-44-7

Fluticasone furoate is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.

YN483497 20-Hydroxyganoderic Acid G 400604-12-8

20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of theGanoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC50 of 21...

YN482813 Acetylshengmanol Arabinoside 402513-88-6

Acetylshengmanol Arabinoside is isolated fromCimicifugae rhizoma.

YN320971 FTY720 (S)-Phosphate 402616-26-6

FTY720 (S)-Phosphate is an agonist ofS1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

YN320311 Nebentan 403604-85-3

Nebentan (YM598 free base) is a potent, selective and orally active non-peptideendothelin ETAreceptorantagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human end...

YN1710007 HEMADO 403842-38-6

HEMADO is a potent and selectiveadenosine A3receptoragonist with aKiof 1.1nM at the human A3subtype.

YN372309 Salubrinal 405060-95-9

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

YN330335 W-54011 405098-33-1

W-54011 is a potent and orally active non-peptideC5a receptorantagonist. W-54011 inhibits the binding of125I-labeledC5ato human neutrophils with aKivalue of 2.2nM. W-54011 also inhibitsC5a-induced intracellular Ca2+mobilization,...

YN410041 ACHP Hydrochloride 406209-26-5

ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selectiveIKK-βinhibitor with an IC50 of 8.5nM.

YN410058 IKK-IN-1 406211-06-1

IKK-IN-1 is an inhibitor ofIKKextracted from patent WO2002024679A1, compound example 18-13.

YN360039 CaCCinh-A01 407587-33-1

CaCCinh-A01 (TMEM16 Blocker I) is a blocker of TMEM16A with IC50 of 2.1 μM. CaCCinh-A01 is also an inhibitor of calcium-activated chloride channel (CaCC) with IC50 of ~ 10 μM.