YN270612 Adalimumab 331731-18-1

Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor α (TNF-α).

YN480401 Abatacept 332348-12-6

Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept is a selective T-cell co-st...

YN270015 C 87 332420-90-3

C87 is a novel small-molecule TNFαinhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73μM.

YN450043 CUR61414 334998-36-6

CUR61414 is a novel, potent and cell permeableHedgehog signaling pathway inhibitor(IC50=100-200nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds tosmoothened (Smo)with aKivalue of 44nM. CU...

YN330179 CAY10404 340267-36-9

CAY10404 is a potent and highly selectivecyclooxygenase-2 (COX-2)inhibitor with an IC50 of 1nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM). CAY10404 is a potent inhibitor ofPKB/Akt and MAPKsignali...

YN483603 Ginsenoside Rh8 343780-69-8

Ginsenoside Rh8 is a saponin composition of roots ofPanax ginseng. Ginsenosides are the major active pharmacological components of ginseng.

YN330319 Leukadherin-1 344897-95-6

Leukadherin-1, a specific agonist of the leukocyte surface integrinCD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50of 4μM. Leukadherin-1 enhances leukocyte adhesion to lig and s (such as IC...

YN360681 AZD9056 hydrochloride 345303-91-5

AZD9056 hydrochloride is a selective orally active inhibitor ofP2X7which plays a significant role in inflammation and pain-causing diseases.

YN372884 Taurocholic acid sodium salt ... 345909-26-4

Taurocholic acid, a bile salt formed in the liver, is the product of conjugation of cholic acid with taurine that is involved in the emulsification of lipids. Its sodium salt is the chief ingredient of the bile of carnivorous animals.

YN320069 Cetirizine Impurity D 346451-15-8

Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamineH1-receptorantagonist. Cetirizine marks antiallergic properties and inhibits...

YN321213 Amelubant 346735-24-8

Amelubant (BIIL 284) is a potent, oral and long actingLTB4receptorantagonist, negligibly binds to LTB4receptor, with Kis of 221nM and 230nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active m...

YN372499 LTV-1 347379-29-7

LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508nM. LTV-1 has the potential for autoimmunity treatment.

YN330333 Emeramide 351994-94-0

Emeramide is a novel lipid-soluble, thiol-redox antioxidant and heavy metal chelator.

YN360559 NS6180 353262-04-1

NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9nM) prevents T-cell activation and inflammation.

YN320257 J-113863 353791-85-2

J-113863 is a potent and selectiveCCR1 (CD18)antagonist with IC50 values of 0.9nM and 5.8 nM for human and mouseCCR1receptors, respectively. J-113863 is also a potent antagonist of the humanCCR3(IC50 of 0.58nM) , ...

YN372256 Balicatib 354813-19-7

Balicatib (AAE-581) is a potent and selective inhibitor of the osteoclastic enzyme cathepsin K.

YN480910 AG-09/1 356776-32-4

AG-09/1 is a specific formyl peptide receptor 1 (FPR1) agonist. N-formyl peptide receptors (FPR) are important in host defense.

YN330012 C29 363600-92-4

TLR2-IN-C29 (C29) is a Toll-like receptor 2 (TLR2) inhibitor that inhibits TLR2/1 and TLR2/6 signaling.

YN481464 TD-198946 364762-86-7

TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.

YN482937 Ginsenoside Rk2 364779-14-6

Ginsenoside Rk2 is a dammarane glycoside isolated from the processed ginseng (SG; Sun Ginseng).