YN330456 Dapsone D8 557794-38-4

Dapsone D8 is a deuterium labeled Dapsone. Dapsone is a potent, blood-brain penetrant and orally activeantibiotic, has bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone is used for dermatologic disorder resea...

YN322016 AZD2098 566203-88-1

AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.

YN330707 TLR1 566914-00-9

TLR1 (compound 4a) is a low molecular weight, cell-penetratingToll/IL-1 receptor/resistance (TIR) domain/BB-Loopmimic. TLR1 inhibits IL-1 receptor-mediated responses.

YN321278 Laropiprant 571170-77-9

Laropiprant is a potent, selectiveDP receptorantagonist with Ki values of 0.57nM and 2.95nM for DP receptor and TP Receptor, respectively.

YN484229 NCX1022 571186-50-0

NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory drug for the treatment of skin inflammation.

YN330253 VAF347 574759-62-9

VAF347 is a cell permeable and highly affinityaryl hydrocarbon receptor (AhR)agonist and inducesAhRsignaling. VAF347 inhibits the development of CD14+CD11b+monocytes from granulo-monocytic (GM stage) precursors. VAF34...

YN440361 R112 575474-82-7

R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor with Ki value of 96 nM.

YN350035 Losmapimod 585543-15-3

Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3.

YN350036 PH-797804 586379-66-0

PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.

YN410082 Bay 65-1942 hydrochloride 600734-06-3

Bay 65-1942 hydrochloride is an ATP-competitive and selectiveIKKβinhibitor.

YN322021 SUN 1334H 607736-84-5

SUN 1334H is a potent, orally active, highly selectiveH1 receptorantagonist, with Kiof 9.7nM.

YN370908 Apremilast 608141-41-9

Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.

YN482346 (R)-Apremilast 608141-44-2

(R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast.

YN321369 Carvedilol phosphate hemihydr... 610309-89-2

Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.

YN370516 RGX-104 610318-03-1

RGX-104 is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

YN370517 RGX-104 free Acid 610318-54-2

RGX-104 free Acid is an orally bioavailable  and  potent liver-X nuclear hormone receptor(LXR)agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

YN5340004 SM 16 614749-78-9

SM 16 is aALK5/ALK4kinase inhibitor with Kis of 10 and 1.5nM, respectively.

YN290445 PD 407824 622864-54-4

PD 407824 is a checkpoint kinaseChk1 and WEE1inhibitor with IC50s of 47 and 97nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.

YN440092 Ki20227 623142-96-1

Ki20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase(CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR...