Chemical structure
Cat.No.
Product Name
CAS no.
Target
BRD6989 is a selective inhibitor of CDK8 and CDK19. BRD6989 upregulates IL-10. BRD6989 is an analog of the natural product cortistatin A (dCA).
YN483985 CLIP (86-100) 648881-58-7
CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding ...
YN440306 BAY 61-3606 dihydrochloride 648903-57-5
BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
Jedi2 is aPiezo1channel activator, but no specific Piezo2 activators. Jedi2 binds to the mouse Piezo1 proteins with a Kdof 2770 μM.
YN320828 GW842166X 666260-75-9
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.
PG-931, an analog of SHU 9119 (HY-P0227), is a potentmelanocortin 4 (MC4) receptor(IC50=0.58nM) agonist and is more selective than for the hMC3R (IC50=55nM) or the hMC5R (IC50=2.4nM). PG-931 can reverse haemorrh...
YN420211 BIO-acetoxime 667463-85-6
BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
DFP00173 is a potent and selectiveaquaporin-3 (AQP3)inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and A...
YN290377 Kif15-IN-1 672926-32-8
Kif15-IN-1 is an inhibitor of the mitoticKinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.
YN290378 Kif15-IN-2 672926-33-9
Kif15-IN-2 is an inhibitor of the mitotickinesin Kif15, and is used for the research of cellular proliferative diseases.
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase(HNE), with an IC50 of 20nM. BAY-678 is also nominated as a chemical probe to the public via the Structural ...
YN483032 Megastigm-7-ene-3,5,6,9-tetra... 680617-50-9
Megastigm-7-ene-3,5,6,9-tetraol (Megastigma-7-en-3,5,6,9-tetraol) is a diterpenoid analogue in the aerial parts ofIsodon melissoides. Megastigm-7-ene-3,5,6,9-tetraol is also inVigna luteola and has anti-inflammatory bioactivity.
BNTA, a potentextracellular matrix (ECM)modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activatingsuperoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation...
PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
YN321024 Vercirnon 698394-73-9
Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist ofCCR9. Vercirnon inhibits CCR9-mediated Ca2+mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4nM, respectiv...
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
YN320451 HAMI 3379 712313-35-4
HAMI 3379 is a potent and selectiveCysteinyl leukotriene (CysLT2) receptorantagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation.
APETx2, a sea anemone peptide fromAnthopleura elegantissima, is a selective and reversibleASIC3inhibitor, with an IC50 of 63nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 coul...
YN330294 Vidofludimus 717824-30-1
Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Phase 2.
YN320455 Syk Inhibitor II 726695-51-8
Syk Inhibitor II is a potent, high selective and ATP-competitiveSykinhibitor with an IC50 of 41nM. Syk Inhibitor II inhibits5-HTrelease from RBL-cells with an IC50 of 460nM. Syk Inhibitor II shows less potent ag...
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