YN321904 2-Furoyl-LIGRLO-amide 729589-58-6

2-Furoyl-LIGRLO-amide is a potent and selectiveproteinase-activated receptor 2 (PAR2)agonist with apD2value of 7.0..

YN440413 BAY 61-3606 732983-37-8

BAY 61-3606 is an orally available, ATP-competitive, reversible and highly selectiveSykinhibitor with a Ki of 7.5nM and an IC50 of 10nM. BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BA...

YN320671 Batefenterol 743461-65-6

Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.

YN350034 VX-702 745833-23-2

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.

YN410059 JSH-23 749886-87-1

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

YN1710001 GS-6201 752222-83-6

GS-6201 (CVT-6883) is a selectiveadenosine A2B receptorantagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22nM). GS-6201 reduces caspase-1 activity in the heart, and atten...

YN260005 m-PEG8-NHS ester 756525-90-3

PF-06380101 (Aur0101), an auristatinmicrotubuleinhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared ...

YN410068 CID-2858522 758679-97-9

CID-2858522 is a highly potent and selective antigen receptor-mediatedNF-κBactivation inhibitor with an IC50 of 70nM.

YN260072 Mal-PEG1-acid 760952-64-5

Mal-PEG1-acid is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

YN482400 Hederacoside D 760961-03-3

Hederacoside D is one of the bioactive saponins fromHedera helix, and plays pivotal roles in the overall biological activity.

YN321116 Cetirizine D8 774596-22-4

Cetirizine D8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamineH1-receptorantagonist. Cetirizine...

YN372263 Oglemilast 778576-62-8

Oglemilast (GRC 3886) is a potent and orally activephosphodiesterase-4 (PDE4)inhibitor with an IC50 of 0.5nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro a...

YN251519 Dehydroandrographolide succin... 786593-06-4

A herb extraction

YN330692 COX-2-IN-1 787623-48-7

COX-2-IN-1 is potent and slectiveCOX-2 inhibitor with an IC50 of 3.9μM.

YN440384 c-Fms-IN-2 791587-67-2

c-Fms-IN-2 is aFMS kinaseinhibitor with an IC50 of 0.024μM.

YN484268 Itch-Targeting Compound 1 793674-76-7

Itch-Targeting Compound 1 is an anti-itching agent.

YN251822 PBP10 794466-43-6

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor offormyl peptide receptor 2 (FPR2)over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity agai...

YN330358 Nodinitib-1 799264-47-4

ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.

YN370308 GSK256066 801312-28-7

GSK 256066 is a selective and high-affinityphosphodiesterase 4 (PDE4)inhibitor, with an IC50 of 3.2 pM for PDE4B. GSK 256066 is developed for the research of chronic obstructive pulmonary disease.

YN321049 AZD1981 802904-66-1

AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2.