Chemical structure
Cat.No.
Product Name
CAS no.
Target
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin inducesapoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.
YN360316 Resolvin D2 810668-37-2
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhib...
YN330679 Ustekinumab 815610-63-0
Ustekinumab is an anti-IL-12/IL-23IgG1κ human monoclonal antibody.
YN370788 PF-00356231 hydrochloride 820223-77-6
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating lig and and inhibitor of matrix metalloproteinaseMMP-12(IC50=1.4μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 co...
YN483718 Raddeanoside R17 824401-07-2
Raddeanoside R17 (Pulchinenoside E3) is a saponins compound that can be isolated from the root ofPulsatilla koreana. Raddeanoside R17 shows anti-inflammatory effects.
YN330653 Di-O-methyldemethoxycurcumin 824951-60-2
Di-O-methyldemethoxycurcumin, a curcuminoid analog isolated from the medicinal plantCurcuma longaL., inhibitsIL-6production with an EC50of 16.20 μg/mL. Anti-inflammatory and antioxidant properties.
YN350179 Acumapimod 836683-15-9
Acumapimod (BCT197) is an orally activep38 MAPkinase inhibitor, with an IC50 of less than 1μM for p38α.
YN440142 R406 free base 841290-80-0
R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.
CJ-42794 is a selective prostagl and in E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the hum...
YN440193 Lck Inhibitor 847950-09-8
Lck Inhibitor is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7nM.
YN483926 MARK Substrate 847991-34-8
MARK Substrate is a MARK substrate peptide.
YN372322 Alvelestat 848141-11-7
Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
YN290424 Pemafibrate 848259-27-8
Pemafibrate is a highly selectivePPARαagonist, with an EC50 of 1nM.
YN480738 Fluorofenidone 848353-85-5
Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppres...
YN483286 Lup-20(29)-en-28-oic acid 848784-85-0
Lup-20(29)-en-28-oic acid, a triterpenoid saponins ofPulsatilla koreanaRoot, possesses anti-inflammatory and anti-tumor effect.
cGAMP (Cyclic GMP-AMP; 3',3'-cGAMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING lig and .
ML604086 is a selectiveCCR8inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+concentrations.
YN372705 Alogliptin Benzoate 850649-62-6
Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
YN450103 GSK269962A 850664-21-0
GSK269962A (GSK 269962) is a potentROCKinhibitor with IC50s of 1.6 and 4nM for recombinant humanROCK1 and ROCK2respectively. GSK269962A has anti-inflammatory and vasodilatory activities.
YN480755 Umirolimus 851536-75-9
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used drug-eluting stent (DES) applications.
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