YN320965 Timapiprant 851723-84-7

Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known asCRTH2) antagonist. Timapiprant (OC000459) potently displaces [3H] PGD2 from human recombinant DP2(Ki=13nM), r...

YN321280 MK-0812 Succinate 851916-42-2

MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.

YN320293 Ponesimod 854107-55-4

Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.

YN320964 NBI-74330 855527-92-3

NBI-74330 is a potent antagonist forCXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Kiof 1.5 and 3.2nM, respectively.

YN330251 4-Methylamino antipyrine hydr... 856307-27-2

4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibitsCOX. Metamizole is an nonopioid analgesic drug and can be used...

YN410021 Triphala 857906-76-4

Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts ofTerminalia chebula,Terminalia bellerica, and Phyllanthus emblica. Triphala inhibitsNF-κBactivation. Triphala exertsantifungalaction. An...

YN260013 SPB 858128-57-1

Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

YN320432 L 888607 860033-06-3

L 888607 is a potent, and selectiveCRTH2(also known as DP2) agonist with a Ki of 0.8nM.

YN310229 Resveratrol analog 1 861446-16-4

Resveratrol analog 1 is an analog of Resveratrol (HY-16561), compound 48. Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

YN350132 Ralimetinib dimesylate 862507-23-1

Ralimetinib (LY2228820) is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, does not alter p38 MAPK activation. Phase 1/2.

YN410065 GSK319347A 862812-98-4

GSK319347A is a dual inhibitor of TBK1 and IKKεwith IC50s of 93nM and 469nM, respectively. GSK319347A also inhibitsIKK2with an IC50 of 790nM.

YN371591 Glyco-Obeticholic acid 863239-60-5

Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist.

YN371590 Tauro-Obeticholic acid 863239-61-6

Tauro-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.

YN482524 Dehydroandrographolide succin... 863319-40-8

Dehydro and rographolide succinate (potassium sodium salt), extracted from herbal medicine and rographis paniculata(Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because ...

YN350256 Licochalcone E 864232-34-8

Licochalcone E, a flavonoid compound isolated fromGlycyrrhiza inflate, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of Akt and MAPKactivation.

YN350057 AMG-548 864249-60-5

AMG-548, an orally active and selectivep38αinhibitor (Ki=0.5nM), shows slightly selective overp38β(Ki=36nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole bloo...

YN321038 Revefenacin 864750-70-9

Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.

YN483675 Stachyanthuside A 864779-30-6

Stachyanthuside A is an ellagic acid glycoside isolated from the leaves ofDiplopanax stachyanthus.

YN481094 ERAP1-IN-1 865273-97-8

ERAP1-IN-1 is anendoplasmic reticulum aminopeptidase 1 (ERAP1)inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates.

YN330046 INF39 866028-26-4

INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.