YN440030 ISCK03 945526-43-2

ISCK03 is a cell-permeable inhibitor of stem-cell factor (SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.

YN360934 Ophiopogonin D 945619-74-9

Ophiopogonin D, isolated from the tubers ofOphiopogon japonicus, is a rare naturally occurring C29steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocatio...

YN320448 GSK726701A 945721-87-9

GSK726701A is a novelprostagl and in E2 receptor 4 (EP4)partial agonist with apEC50of 7.4.

YN371091 Lotamilast 947620-48-6

Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8nM.

YN310079 Delcasertib 949100-39-4

Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction ...

YN320966 Timapiprant sodium 950688-14-9

Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known asCRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [3H] PGD2 from human rec...

YN484043 Thioredoxin reductase peptide 950890-23-0

Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research. Thioredoxin reductase acts as a reductant of disulfide-containing proteins and plays crucial role in...

YN483107 4''-methyloxy-Genistin 950910-16-4

4''-methyloxy-Genistin, an isoflavone methyl-glycoside, is isolated fromCordyceps militarisgrown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities.

YN321245 Danirixin 954126-98-8

Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist.

YN370169 GKT136901 955272-06-7

GKT136901 is a potent, selective and orally active inhibitor ofNADPH oxidase (NOX1/4), with Kis of 160 and 165nM, respectively. GKT136901 also is a selective and direct scavenger of peroxynitrite. GKT136901 can be u...

YN420112 PI-3065 955977-50-1

PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, >70-fold selectivity over other PI3K family members.

YN320756 Betamethasone hydrochloride 956901-32-9

Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis.

YN371582 5β-​Dutasteride 957229-52-6

5β-Dutasteride is the S configuration of Dutasteride. 5β-Dutasteride is a potent inhibitor of both5 alpha-reductase isozymes.

YN480761 DPA-714 958233-07-3

DPA-714 is a high affinity translocator protein(TSPO)lig and (Ki=7nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivoimaging using positron emission tomography.18FDPA...

YN481417 (±)-Naproxen-d3 958293-79-3

(±)-Naproxen-d3 ((Rac)-Naproxen-d3) is the deuterium labeled (±)-Naproxen. (±)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID).

YN1710019 N-Boc-piperazine-C3-COOH 959053-53-3

N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).

YN440157 cFMS Receptor Inhibitor I... 959860-85-6

cFMS Receptor Inhibitor II is aCSF1Rkinase inhibitor. CSF-1 is a cytokine.

YN371355 ONX-0914 960374-59-8

ONX-0914 (PR-957) is a potent and selective inhibitor ofimmunoproteasome subunit LMP7.

YN321182 Elubrixin tosylate 960495-43-6

Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally activeCXCR2antagonist and anIL-8 receptorantagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260...

YN480424 CORM-401 1001015-18-4

CORM-401 is an oxidant-sensitive CO-releasing molecule, can be used in the research of inflammatory and oxidative stress-mediated pathologies.