Chemical structure
Cat.No.
Product Name
CAS no.
Target
FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis.
PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- ...
GNF362 is a selective, potent, and orally bioavailable inhibitor ofinositol trisphosphate 3’ kinase B (Itpkb)with an IC50 of 9nM. GNF362 also inhibits Itpka and Itpkc with IC50 values of 20nM and 19nM, respectively. ...
CR4056 is a selective inhibitor of human recombinant MAO-Awith an IC50 of 202.7nM. CR4056 is also a lig and ofimidazoline-2 receptor(I2R) with an IC50 of 596nM.
YN360375 Asivatrep 1005168-10-4
Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.
MK-2894 is a potent, selective, orally active and high affinity (Ki=0.56nM) full antagonist againstE prostanoid receptor 4 (EP4 receptor)(IC50=2.5nM). MK-2894 possesses potent anti-inflammatory activity in animal models of pai...
YN320272 MK-2894 sodium salt 1006036-88-9
MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56nM) full antagonist againstE prostanoid receptor 4 (EP4 receptor)(IC50=2.5nM). MK-2894 sodium salt possesses potent anti-inflammatory activity...
YN350124 p38 MAPK-IN-1 1006378-90-0
p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor ofp38 MAPKwith IC50 of 68nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.
YN260251 Maleimide-DOTA 1006711-90-5
Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
YN370446 Razuprotafib 1008510-37-9
Razuprotafib, a proteintyrosine phosphatase ß (HPTPß)inhibitor, extracted from patent WO2019165349A1, compound AA34, has an IC50 of 50nM. Razuprotafib is effective for activation of Tie-2, and is protective against acute ...
YN1710023 IRAK inhibitor 4 1012104-68-5
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
YN1710022 IRAK inhibitor 3 1012343-93-9
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
ML-030 is a potentPDE4inhibitor, with IC50 of 6.7nM, 12.9nM, 48.2nM, 37.2nM, 452nM and 49.2nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1, and PDE4D2, respectively.
YN370058 Avadomide 1015474-32-4
Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (C...
YN360095 Gefapixant 1015787-98-0
Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrim...
RV01 is an analogue of resveratrol, inhibits DNA damage, reducesacetaldehyde dehydrogenase 2 (ALDH2)mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity. RV01 decreasesiNOSexpression, with...
YN321558 Pirfenidone D5 1020719-62-3
Pirfenidone D5 (AMR69 D5) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuatesCCL2 and CCL12production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reducesTGF-β2pr...
YN440244 Fostamatinib Disodium 1025687-58-4
R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
YN300053 Lifitegrast 1025967-78-5
Lifitegrast is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.
YN320145 VUF10460 1028327-66-3
VUF10460 is a non-imidazole histamineH4receptor agonist; binds to rat H4 receptor with a pKi of 7.46.
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