YN350143 BMS-582949 hydrochloride 912806-16-7

BMS-582949 hydrochloride is an orally active and highly selectivep38α MAPKinhibitor, with an IC50 of 13nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory...

YN320429 PS372424 914291-61-5

PS372424, a three amino-acid fragment of CXCL10, is a specific humanCXCR3agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.

YN440246 Fostamatinib disodium hexahyd... 914295-16-2

Fostamatinib (R788) disodium (Tamatinib Fosdium) hexahydrate, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay.

YN350206 Cot inhibitor-1 915365-57-0

Cot inhibitor-1 (compound 28) is a selectivetumor progression loci-2 (Tpl2) kinaseinhibitor with an IC50 of 28nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7nM.

YN380018 (2-Chloropyridin-4-yl)methana... 916210-98-5

(2-Chloropyridin-4-yl)methanamine hydrochloride is a selectiveLOXL2inhibitor with an IC50 of 126nM.

YN370477 GS143 916232-21-8

GS143 is a selec­tiveIκBα ubiquitinationinhibitor with an IC50 of 5.2μM for SCFβTrCP1-mediatedIκBα ubiquitylation. GS143 sup­pressesNF-κBacti­va­tion and tran­scrip­tion of tar­get genes and does not in...

YN250189 MS417 916489-36-6

MS417 is a selective BET-specificBRD4inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46nM and Kds of 36.1, 25.4nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7μM).

YN481326 Resolvin D3 916888-47-6

Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation.

YN482837 5,7,4'-Trihydroxy-8-Methylfl... 916917-28-7

5,7,4'-Trihydroxy-8-Methylflavanone (Compound 2) is a flavanone isolated fromQualea gr and iflora.

YN322023 Ansofaxine hydrochloride 916918-84-8

Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibitsserotonin,dopamine and norepinephrinereuptake with IC50 values of 723, 491 and 763nM, respectively.

YN340011 AS1517499 919486-40-1

AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.

YN250663 RRx-001 925206-65-1

RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia.

YN1710028 LAS101057 925676-48-8

LAS101057 is a potent, selective, and orally efficaciousA2B receptorantagonist.

YN372730 Acitretin sodium 925701-88-8

Acitretin sodium(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin sodium is a second-generation, systemic retinoid that has been approved for the treatment of psoriasis sin...

YN330006 Toll-like receptor modulator 926927-42-6

Toll-like receptor modulator is a modulator of TLR7/8, which modulates immune function.

YN372388 Osilodrostat 928134-65-0

LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase, an enzyme catalyzing the final step of cortisol synthesis.

YN1710021 IRAK inhibitor 2 928333-30-6

IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor .

YN320520 AZ084 929300-19-6

AZ084 is a potent, selective, allosteric and oral activeCCR8antagonist, with a Ki of 0.9nM. Has potential to treat asthma.

YN480632 ADAMTS-5 Inhibitor 929634-33-3

ADAMTS-5 Inhibitor is a potentADAMTS-5 (aggrecanase-2)inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).

YN321090 Asapiprant 932372-01-5

Asapiprant is a potent and selectiveDP1receptorantagonist with a Ki of 0.44nM.