YN330243 MF63 892549-43-8

MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9nM and 1.3nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.

YN340127 BD750 892686-59-8

BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell prol...

YN300010 BMS-688521 893397-44-9

BMS-688521 is a highly potent, orally active inhibitor of theLFA-1/ICAMinteraction, with an IC50 of 2.5nM in the adhesion assay and an IC50 of 60nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosi...

YN330387 ST 2825 894787-30-5

ST 2825 is a specificMyD88dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity.

YN370031 Trifarotene 895542-09-3

Trifarotene (CD5789) is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500nM forRARγ,RARβ and RARα, respectively.

YN330411 Imiquimod maleate 896106-16-4

Imiquimod maleate (R 837 maleate) is a selectivetoll like receptor 7 (TLR7)agonist acting as an immune response modifier. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the res...

YN320789 MSX-122 897657-95-3

MSX-122 is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).

YN350161 Tanzisertib 899805-25-5

Tanzisertib (CC-930) is a potentJNK1/2/3inhibitor with IC50s of 61/7/6nM, respectively.

YN480527 ACP-105 899821-23-9

ACP-105 is an orally available, selective amd potent and rogen receptormodulator (SARM), withpEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.

YN440245 Fostamatinib 901119-35-5

Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.

YN481677 FPR Agonist 43 903895-98-7

FPR Agonist 43 (compound 43) is a dualformyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALXagonist.

YN371129 KPLH1130 906669-07-6

KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice.

YN370468 Crisaborole 906673-24-3

Crisaborole is a small-molecule, boron-based, selective PDE4 inhibitor and has broad-spectrum anti-inflammatory activity.

YN320013 SCH 546738 906805-42-3

SCH 546738 is a potent, orally active and non-competitiveCXCR3antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4nM in multiple experiments.

YN480594 Inflachromene 908568-01-4

Inflachromene, a microglial inhibitor, binds toHMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions ofHMGB and reduces neuronal damage. Inflachromene can be...

YN440177 CGI-1746 910232-84-7

CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM.

YN1710005 BAY 60-6583 910487-58-0

BAY 60-6583 is a potent and high-affinity agonist ofadenosine A2Breceptor (EC50= 3nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750nM, 340nM and 330nM,...

YN372724 Adapalene sodium salt 911110-93-5

Adapalene sodium salt(CD 271; Differin), a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).

YN450095 Belumosudil 911417-87-3

KD025 is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2.

YN320808 AZD8797 911715-90-7

AZD8797 is an allosteric non-competitive and orally active antagonist of the humanCX3CR1receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800nM, respectively.