YN370848 PF-4191834 1029317-21-2

PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the5-Lipoxygenase (5-LOX)(IC50=229nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity to...

YN480432 UNC3230 1031602-63-7

UNC3230 is a potent, selective and ATP-competitivePIP5K1Cinhibitor with an IC50 of ~41nM. UNC3230 also inhibitsPIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC...

YN320537 GSK1292263 1032823-75-8

GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes. Phase 2.

YN330070 HPGDS inhibitor 1 1033836-12-2

HPGDS inhibitor 1 is a potent, selective and orally activeHematopoietic Prostagl and in D Synthase (HPGDS)inhibitor with anIC50s of 0.6nM and 32nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 d...

YN320354 AZD5423 1034148-04-3

AZD5423 is an inhaled, potent, selective, and non-steroidalglucocorticoid receptor (GR)modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.

YN350087 p38α inhibitor 1 1034189-82-6

p38α inhibitor 1 is ap38αinhibitor extracted from patent WO 2008076265 A1.

YN321227 GSK2018682 1034688-30-6

GSK2018682 is an agonist forS1P1 and S1P5 receptor withpEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.

YN320421 PF-03654746 Tosylate 1039399-17-1

PF-03654746 Tosylate is a potent and selectivehistamine H3 receptorantagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms. PF-03654746 Tosylate has potential for treatment of human c...

YN320002 Budesonide impurity C 1040085-99-1

Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist.

YN1710020 IRAK inhibitor 1 1042224-63-4

IRAK inhibitor 1 is a potentIRAK-4inhibitor with IC50 of 216nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801μM, and >10μM, respectively.

YN1710024 IRAK inhibitor 6 1042672-97-8

IRAK inhibitor 6 is a selective Interleukin-1 receptor-associated kinase 4(IRAK4) inhibitor with IC50 of 0.16 μM.

YN260029 m-PEG6-azide 1043884-49-6

N-Boc-diethanolamine is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs).

YN330681 Benralizumab 1044511-01-4

Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotox...

YN321084 Fosdagrocorat 1044535-58-1

Fosdagrocorat (PF-04171327) is a dissociatedglucocorticoid receptoragonist.

YN310298 PKC-IN-1 1046787-18-1

PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventionalPKCenzymes with Kis of 5.3 and 10.4nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808nM for PKCα, PK...

YN260423 N3-PEG3-CH2CH2COOH 1056024-94-2

N3-PEG3-CH2CH2COOH a PEG-based PROTAClinker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEGADClinker used in the synthesis...

YN321405 Mizolastine dihydrochloride 1056596-82-7

Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Mizolastine is a histamine H1-receptor antago...

YN350059 AL 8697 1057394-06-5

AL 8697 is a specific and orally activep38α MAPKinhibitor with an IC50 of 6nM. AL 8697 displays 14-fold greater inhibition of p38α compared to p38β (IC50=82nM), and 300-fold selectivity for p38α over a panel of 91 kina...

YN260161 m-PEG5-succinimidyl carbona... 1058691-00-1

m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEGADClinker used in the synthesis of antibody-drug conjugates (ADCs).

YN420207 WAY-600 1062159-35-6

WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308) selective for mTOR than PI3Kα (>100-fold) a...