YN470008 ZK168281 186371-96-0

ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3analog and a pureVDRantagonist with aKdvalue of 0.1nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.

YN484248 CP-319340(free base) 186390-35-2

CP-319340 free base is a microsomal triglyceride transfer protein (MTP) inhibitor.

YN481195 CP-91149 186392-40-5

CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.

YN320870 ML 10302 hydrochloride 186826-17-5

ML 10302 hydrochloride is a potent and selective5-HT4receptoragonist, with an EC50 of 4nM。ML 10302 hydrochloride displays more than 680-fold selectivity over5-HT3receptor in binding assay.

YN420134 GSK-3β inhibitor 1 187325-53-7

GSK-3β inhibitor 1 (compound 3a) is aglycogen synthase kinase 3β (GSK-3β)inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9nM.

YN360673 Rimeporide 187870-78-6

Rimeporide (EMD-87580) is a potent and selective inhibitor of theNa+/H+exchanger (NHE-1).

YN360674 Rimeporide hydrochloride 187870-95-7

Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of theNa+/H+exchanger (NHE-1).

YN370267 MAFP 188404-10-6

MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor ofcPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor ofan and amide amidase.

YN372242 Lapaquistat 189059-71-0

Lapaquistat (T-91485), acholesterol biosynthesisinhibitor, is the active metabolite of TAK-475. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy.

YN372387 Lapaquistat acetate 189060-13-7

Lapaquistat acetate (TAK-475) is asqualene synthaseinhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD)...

YN320825 Tegaserod maleate 189188-57-6

Tegaserod Maleate is a hydrogen maleate salt form of tegaserod, which is a 5-HT4 receptor partial agonist and binds with high affinity to 5-HT4 receptors. It has limited affinity for 5-HT1 receptors and no appreciable affinity for ...

YN440326 KU14R 189224-48-4

KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.

YN480372 Mogroside VI 189307-15-1

Mogroside VI, a triterpenoid glycoside isolated from the extracts ofLuo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.

YN373402 N-Caffeoyl O-methyltyramine 189307-47-9

N-Caffeoyl O-methyltyramine is a class of alkaloid isolated fromCuscuta reflexawith strong inhibitory activity againstα-glucosidase(IC50 of 103.58μM).

YN371586 Ezetimibe phenoxy glucuronide 190448-57-8

Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.

YN320336 BIBO3304 TFA 191868-14-1

BIBO3304 TFA is a potent, orally active, and selectiveneuropeptide Y (NPY) Y1 receptorantagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72nM, respectively).

YN373324 Mulberroside F 193483-95-3

Mulberroside F is one of the main bioactive constituents in mulberry (Morus albaL.). Mulberroside F shows inhibitory effects ontyrosinaseactivity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging act...

YN321236 Pumosetrag Hydrochloride 194093-42-0

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available5-HT3partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

YN371598 Raloxifene N-Oxide 195454-31-0

Raloxifene N-Oxide is a Raloxifene oxidative degradation product.

YN330279 AP20187 195514-80-8

AP20187 (B/B Homodimerizer) is a cell-permeable lig and used to dimerizeFK506-binding protein(FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.