YN372321 FG-2216 223387-75-5

FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2.

YN1720035 GLP-2(1-33)(human) 223460-79-5

GLP-2(1-33) (human) is an enteroendocrine hormone which can bind to theGLP-2 receptor and stimulate the growth of intestinal epithelium.

YN372657 CPA inhibitor 223532-02-3

CPA inhibitor (Carboxypeptidase inhibitor; compound 5) is a potentcarboxypeptidase A (CPA)inhibitor with a Ki of 0.32μM.

YN270059 EP1013 223568-55-6

EP1013 is a broad-spectrumcaspaseselective inhibitor, used in the research of type 1 diabetes.

YN370915 (Rac)-Brassinazole 224047-41-0

Brassinazole is a potent inhibitor of brassinosteroid (BR) biosynthesis with IC50 of ~ 1 μM, that has been developed to probe the myriad functions of brassinosteroids. Brassinosteroids are a class of phytohormones with essent...

YN481437 Emapunil 226954-04-7

Emapunil(AC-5216) is a novel mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO) ligand. Emapunil(AC-5216) showes high affinity for MBRs prepared from rat whole brain with Ki of 0.297 nM and IC50...

YN251819 Apelin-36(rat, mouse) 230299-95-3

Apelin-36(rat, mouse) is an endogenous orphan G protein-coupled receptorAPJagonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4nM, and potently inhibits cAMP production with an EC50 of 0.52nM. Apeli...

YN371163 α-D-Glucose-1-phosphate dis... 230954-92-4

α-D-Glucose-1-phosphate disodium hydrate is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium hydrate can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiot...

YN370968 TCS 401 243966-09-8

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

YN481733 LR-90 245075-84-7

LR-90 is anadvanced glycation end product (AGE)inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

YN370324 Lidorestat 245116-90-9

Lidorestat (IDD-676) is a potent, selective and orally activealdose reductaseinhibitor with an IC50 of 5nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces catara...

YN320211 BIIE-0246 246146-55-4

BIIE-0246 is a potent and highly selectivenon-peptide neuropeptide Y (NPY) Y2receptor antagonist, with an IC50 of 15nM.

YN481683 Aramchol 246529-22-6

Aramchol (C20-FABAC) is a conjugate of cholic acid and arachidic acid that could inhibit stearoyl coenzyme A desaturase 1 (SCD1) activity. Aramchol has potential use in nonalcoholic fatty liver disease (NAFLD) and nonal...

YN484125 Insulin β Chain Peptide (1... 247044-67-3

Insulin β Chain Peptide (15-23), also known as INS, is an insulin-derived peptide recognized by islet-associated T cells. The Insulin β Chain Peptide (15-23) tetramer stained the INS-reactive CTL clone G9C8, but neither...

YN480064 Paquinimod 248282-01-1

Paquinimod is aS100A9 inhibitor, which prevents S100A9 binding toTLR-4.

YN372398 Teglicar 250694-07-6

Teglicar is a selective and reversible inhibitor of liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1). Teglicar reduces ketogenesis and glucose production, decreases gluconeogenesis and improves glucose homeostasis. T...

YN372545 Ertiprotafib 251303-04-5

Ertiprotafib is an inhibitor ofPTP1B, IkB kinase β (IKK-β), and a dualPPARα and PPARβagonist, with an IC50 of 1.6μM for PTP1B, 400nM for IKK-β, an EC50 of ~1μM for PPARα/PPARβ.

YN290418 Tesaglitazar 251565-85-2

Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4μM and 3.6μM for rat PPARα and human PPARα, respe...

YN372377 AZD7545 252017-04-2

AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.

YN251818 Apelin-36(human) 252642-12-9

Apelin-36(human) is an endogenous orphan G protein-coupled receptorAPJagonist, with an EC50 of 20nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC50=8.61). Apelin-36 has been l...