YN370410 Zofenopril 81872-10-8

Zofenopril is anangiotensin-converting enzyme(ACE) inhibitor with an IC50 of 81μM.

YN482903 Polyphyllin H 81917-50-2

Polyphyllin H, the major active component isolated fromRhizoma Paridis(named chonglou in Chinese), have been widely used in traditional Chinese medicinal preparations to treat inflammation, fracture and convulsion.

YN481583 Atomoxetine hydrochloride 82248-59-7

Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

YN251642 Gomisin M2 82425-45-4

Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits ofSchis and ra rubriflorawith anti-HIVactivity (EC50of 2.4μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzhei...

YN360839 Bifenthrin 82657-04-3

Bifenthrin is a synthetic pyrethroid insecticide that prolongs opening of sodium channels resulting in membrane depolarization and conductance block in the insect nervous system. Bifenthrin is effective againstA. gambiae and C. quinqu...

YN360136 DCPIB 82749-70-0

DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK and inhibits TRESK, TASK1 and T...

YN321652 Nefazodone hydrochloride 82752-99-6

an agonist of the vitamin D receptor (VDR) signaling pathway

YN330510 Echinacoside 82854-37-3

Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.

YN310074 Bryostatin 1 83314-01-6

Bryostatin 1 is a natural macrolide isolated from the bryozoanBugula neritina and is a potent and central nervous system (CNS)-permeablePKCmodulator. Bryostatin 1 binds to the isolated C1 domain ofMunc13-1 and the full-length...

YN321922 Dynorphin B (1-13) 83335-41-5

Dynorphin B (1-13) acts as an agonist onopioid κ-receptor.

YN484005 α-Neoendorphin (1-8) 83339-89-3

α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide.

YN321923 PL-017 83397-56-2

PL-017 is a potent and selectiveμ opioid receptoragonist with an IC50 of 5.5nM for125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats.

YN483964 α-Casein (90-95) 83471-50-5

α-Casein (90-95) is a peptide fragment of α-Casein.

YN322086 Fenmetozole Tosylate 83474-08-2

Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizesα2-adrenergic receptor, and acts as an antidepressant drug.

YN1730117 Org-10490 83507-02-2

Org-10490 is an antagonist ofdopamine D1 receptor and dopamine D2 receptor, used for the treatment for psychiatric disease.

YN320320 RHC 80267 83654-05-1

RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. RHC 80267 inhibits cyclooxygenase (COX) activity, <...

YN320290 Ketanserin tartrate 83846-83-7

Ketanserin (R41468) tartrate is a selective5-HT2 receptorantagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11μM).

YN361009 Hydroxy-α-sanshool 83883-10-7

Hydroxy-​α-​sanshool is an alkylamide isolated frompepper, acts as aTRPA1covalent and TRPV1non-covalent agonist, with EC50s of 69 and 1.1 µM, respectively.

YN360793 Lamotrigine 84057-84-1

Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.

YN360802 Ropivacaine 84057-95-4

Ropivacaine hydrochloride is an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM.