SB-218078
Cat. No. :YN310080
CAS No. :135897-06-2
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order@ubiochem.com| Product Name: | SB-218078 |
| CAS NO.: | 135897-06-2 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 393.39 |
| Molecular Formula: | C₂₄H₁₅N₃O₃ |
| SMILES: | O=C1NC(C(C2=C3N(C4CCC5O4)C6=CC=CC=C62)=C1C7=C3N5C8=CC=CC=C78)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SB-218078 is a potent, selective, ATP-competitive and cell-permeablecheckpoint kinase 1 (Chk1)inhibitor that inhibitsChk1phosphorylation of cdc25C with an IC50 of 15nM. SB-218078 is less potently inhibitsCdc2(IC50 of 250nM) and PKC(IC50 of 1000nM). SB-218078 causesapoptosisby DNA damage and cell cycle arrest . |
| IC50&Target: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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