Pexidartinib hydrochloride
Cat. No. :YN440365
CAS No. :2040295-03-0
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order@ubiochem.com| Product Name: | Pexidartinib hydrochloride |
| CAS NO.: | 2040295-03-0 |
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| Molecular Weight: | 454.28 |
| Molecular Formula: | C₂₀H₁₆Cl₂F₃N₅ |
| SMILES: | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F.Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitivecolony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kitinhibitor, with IC50s of 20 and 10nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cellapoptosis and has anti-cancer activity. |
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