PF 477736
Cat. No. :YN440005
CAS No. :952021-60-2
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order@ubiochem.com| Product Name: | PF 477736 |
| CAS NO.: | 952021-60-2 |
| Chemical Name: | |
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| Molecular Weight: | 419.48 |
| Molecular Formula: | C₂₂H₂₅N₇O₂ |
| SMILES: | O=C([C@@H](C1CCCCC1)N)NC2=CC3=C(C(C=NNC4=O)=C(N3)C5=CN(N=C5)C)C4=C2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49nM, it is also aChk2inhibitor, with a Ki of 47nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2,Fms,Yes,Aurora-A,FGFR3,Flt3, and Ret(IC50=8 (Ki), 10, 14, 23, 23, 25, and 39nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo. |
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