Edicotinib
Cat. No. :YN440120
CAS No. :1142363-52-7
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order@ubiochem.com| Product Name: | Edicotinib |
| CAS NO.: | 1142363-52-7 |
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| Molecular Weight: | 461.60 |
| Molecular Formula: | C₂₇H₃₅N₅O₂ |
| SMILES: | O=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally activecolony-stimulating factor-1 receptor (CSF-1R)inhibitor with an IC50 of 3.2nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20nM and 190nM, respectively. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research. |
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