YN321132 Iloperidone 133454-47-4

Iloperidone is a dopamine (D2)/serotonin (5-HT2) receptor antagonist, used for the treatment of schizophrenia.

YN320291 Sarpogrelate hydrochloride 135159-51-2

Sarpogrelate is a selective 5-HT2A antagonist with pKi values of 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively.

YN321328 Palonosetron 135729-61-2

Palonosetron is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

YN321331 Palonosetron Hydrochloride 135729-62-3

Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

YN321332 (R,R)-Palonosetron Hydroch... 135729-75-8

(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron.

YN321204 RG-12915 136174-04-4

RG-12915 is a selective5-HT3antagonist, with IC50 value of 0.16nM.

YN321108 Agomelatine 138112-76-2

Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.

YN321131 Ziprasidone hydrochloride mon... 138982-67-9

Ziprasidone (CP 88059) hydrochloride monohydrate, an antipsychotic agent, is an orally active combined5-HT (serotonin) and dopamine receptorantagonist. Ziprasidone hydrochloride monohydrate has high affinity for rat (Ki: 3.4nM)/huma...

YN320935 Volinanserin 139290-65-6

Volinanserin is a potent and selective antagonist of 5-HT2receptor, with a Ki of 0.36nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2receptors. Volinanserin has antipsychotic activity.

YN320025 5-HT1A modulator 1 142477-34-7

5-HT1A modulator 1 displays very high affinities for the5HT1A,adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3nM, 10 ± 3nM and 40 ±9nM, respectively.

YN321422 Naratriptan hydrochloride 143388-64-1

Naratriptan HCl is a triptan agent that is used for the treatment of migraine headaches.

YN320238 SB-200646A 143797-62-0

SB-200646A is the first selective5-HT2B/2Cover 5-HT2Areceptor antagonist with pKi values. of 7.5, 6.9 and 5.2 for5-HT2B,5-HT2C and 5-HT2A, respectively. SB-200646A is orally active and has electrophysiological a...

YN320239 SB-200646 143797-63-1

SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor ...

YN321329 Paliperidone 144598-75-4

Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.

YN320243 GR 113808 144625-51-4

GR 113808 is a potent and highly selective5-HT4receptorantagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3receptors.

YN321430 Rizatriptan benzoate 145202-66-0

Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.

YN320500 OPC-14523 free base 145969-30-8

OPC-14523 free base is an orally activesigma and 5-HT1A receptoragonist, with high affinity for sigma receptors (σ1/2IC50=47/56nM), the 5-HT1A receptor (IC50=2.3nM), and the 5-HT transporter (IC50=80nM). OPC-14523 ...

YN320501 OPC-14523 hydrochloride 145969-31-9

OPC-14523 hydrochloride is an orally activesigma and 5-HT1A receptoragonist, with high affinity for sigma receptors (σ1/2IC50=47/56nM), the 5-HT1A receptor (IC50=2.3nM), and the 5-HT transporter (IC50=80nM). OPC-14...

YN320879 Ziprasidone 146939-27-7

Ziprasidone, an antipsychotic agent, is a combined5-HT (serotonin) and dopamine receptorantagonist. Ziprasidone has high affinity for rat (Ki: 3.4nM)/human (2.5nM) 5-HT1A receptors, 5-HT2A (0.42nM), and dopamine D2 receptor...

YN320170 MHP 133 147340-43-0

MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Kiof 69μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.