YN320549 GR 125743 148547-33-5

GR 125743 is a selective5-HT1B/1Dreceptor antagonist, with aKdof 0.61nM for h5-HT1B. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases.

YN321779 Strictosidinic acid 150148-81-5

Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated fromPsychotria myrianthaleaves, inhibits precursor enzymes of5-HTbiosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral anal...

YN321568 Perospirone 150915-41-6

Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively.

YN320012 AP521 151227-08-6

AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94nM.

YN320722 7-Desmethyl-agomelatine 152302-45-9

7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C.

YN320181 Alniditan 152317-89-0

Alniditan is a potent5-HT1B/1Dreceptorsagonist, with IC50 of 1.7 and 1.3nM in HEK 293 cells,and pKivalue of 8.96 and 9.40 for 5-HT1B/1Dreceptors, respectively.

YN321008 Piboserod 152811-62-6

Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.

YN321478 Almotriptan 154323-57-6

Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine. Almotriptan is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults. Almotriptan showed low...

YN321674 Frovatriptan succinate 158930-09-7

Frovatriptan Succinate is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.

YN321673 Frovatriptan succinate hydrat... 158930-17-7

Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high affinity, selective and orally active5-HT1B(pK50of 8.2) and 5-HT1Dreceptoragonist. Frovatriptan succinate hydrate exhibits >10-fold selectiv...

YN321185 SB-215505 162100-15-4

SB-215505 is a potent and subtype-selective5-HT2Breceptor antagonist with pKi values. of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively. SB-215505 increases wakefulness and motor activity in rats.

YN320264 WAY-100635 162760-96-5

WAY-100635 is a potent and selective 5-HT1AReceptor antagonist with a pIC50 of 8.87, an apparent pA2of 9.71. WAY-100635 is a potent and selective5-hydroxytryptamine 1A (5-HT1A) receptorantagonist with an IC50 value of...

YN320839 Vilazodone Hydrochloride 163521-08-2

Vilazodone HCl is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder.

YN320840 Vilazodone 163521-12-8

Vilazodone is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in no...

YN320720 3-Hydroxy agomelatine 166526-99-4

3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a5-HT2Creceptorantagonist with an IC50 of 3.2μM and a Ki of 1.8μM.

YN320721 7-Desmethyl-3-hydroxyagomelat... 166527-00-0

7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine. Agomelatine is amelatonergic(MT1 and MT2) agonist and serotonergic(5HT2C) antagonist.

YN321349 Flibanserin 167933-07-5

Flibanserin is a nonhormonal, centrally acting molecule that acts as an agonist at postsynaptic 5-HT1A receptors and as an antagonist at 5-HT2A receptors.

YN320297 Donitriptan 170912-52-4

Donitriptan is a potent, high efficacy agonist at5-HT1B/1Dreceptors withpKis of 9.4 and 9.3, respectively.

YN322102 LY320135 176977-56-3

LY320135 is a potent and selective antagonist ofCB1receptor, with a Ki of 141nM. LY320135 also binds to5-HT2 and muscarinic receptorswith Kis of 6.4μM and 2.1μM, respectively. LY320135 exhibits neuroprotective effect.

YN321321 Eletriptan hydrobromide 177834-92-3

Eletriptan is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.