YN360710 NNC 55-0396 357400-13-6

NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

YN321984 Urocortin III, mouse 357952-10-4

Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activatesCRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system...

YN410121 Ginsenoside Rk3 364779-15-7

Ginsenoside Rk3 is present in the rootsPanax notoginsengherbs. Ginsenoside Rk3 significantly inhibits TNF-α-inducedNF-κBtranscriptional activity, with an IC50 of 14.24±1.30μM in HepG2 cells.

YN321293 Cinacalcet hydrochloride 364782-34-3

Cinacalcet HCl represents a new class of compounds for the treatment of hyperparathyroidism.

YN372646 Rivaroxaban 366789-02-8

Rivaroxaban is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologic...

YN320316 PZ-128 371131-16-7

PZ-128 (P1pal-7), a cell-penetrating lipopeptide pepducin, is a first-in-class, specific and reversibleprotease-activated receptor-1 (PAR1)antagonist. PZ-128 targets the cytoplasmic surface of PAR1 and interrupts signaling to...

YN360561 Istaroxime hydrochloride 374559-48-5

Istaroxime hydrochloride is aNa+/K+-ATPaseinhibitor (IC50=0.11μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.

YN483781 Kisspeptin-10, human 374675-21-5

Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic ki...

YN480524 PKG drug G1 374703-78-3

PKG drug G1 targets C42 ofPKG Iα. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

YN483018 Piperlotine A 389572-70-7

Piperlotine A is an alkaloid isolated fromPiper lolot, with potent antiplatelet aggregation activity.

YN320958 Prasugrel hydrochloride 389574-19-0

Prasugrel hydrochloride is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.

YN320959 Prasugrel (Maleic acid) 389574-20-3

Prasugrel (PCR 4099) Maleic acid is a thienopyridine and prodrug, inhibits platelet function. Prasugrel Maleic acid is an orally active and potentP2Y12receptor antagonist, and inhibits ADP-induced platelet aggregation.

YN371616 1-Cyclohexyl-3-dodecyl urea 402939-18-8

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selectivesoluble epoxide hydrolase (sEH)inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxy...

YN320311 Nebentan 403604-85-3

Nebentan (YM598 free base) is a potent, selective and orally active non-peptideendothelin ETAreceptorantagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human end...

YN370328 GW3965 hydrochloride 405911-17-3

GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively.

YN481330 2,2,14,14-Tetramethyl-8-oxope... 413624-71-2

2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid is a ketone compound extracted from patent WO2002030860A2, compound example II-9. 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid can be used for the research of cardiovascular dise...

YN360191 SN 6 415697-08-4

SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.

YN320814 Parmodulin 2 423735-93-7

ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.

YN360219 NS5806 426834-69-7

NS5806, a potentpotassium currentactivator, increasesKV4.3/KChIP2peak current amplitudes with an EC50 of 5.3μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2.

YN372430 Dabigatran ethyl ester 429658-95-7

Dabigatran ethyl ester is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity. Dabigatran provides a stable anticoagulation effect without any need to perform periodical laboratory controls. Of note, there is...