YN321170 Sparsentan 254740-64-2

Sparsentan is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.

YN480270 Secoisolariciresinol diglucos... 257930-74-8

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuro...

YN480010 Enecadin 259525-01-4

Enecadin is a neuroprotective agent extracted from patent US 8623823 B2.

YN360432 Norverapamil D7 263175-44-6

Norverapamil D7 is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

YN480444 GR148672X 263890-70-6

GR148672X is atriacyglycerol hydrolase(TGH) inhibitor with an IC50 of 4nM extracted from patent WO 2001016358 A2.

YN290297 GW7647 265129-71-3

GW7647 is a potentPPARαagonist, with EC50s of 6nM, 1.1μM, and 6.2μM for human PPARα, PPARγ and PPARδ, respectively.

YN320066 Ticagrelor 274693-27-5

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM.

YN360627 Rosuvastatin 287714-41-4

Rosuvastatin (ZD 4522) is a competitive HMG-CoAreductase inhibitor with an IC50 of 11nM. Rosuvastatin potently blockshuman ether-a-go-go related gene (hERG)current with an IC50 of 195nM, delayed cardiac repolarization, an...

YN480090 TN1 289479-94-3

TN1 is a potent fetal hemoglobin (HbF) inducer.

YN320947 Avosentan 290815-26-8

Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.

YN372547 AE-3763 291778-77-3

AE-3763 is a peptide-basedhuman neutrophil elastaseinhibitor with an IC50 of 29nM.

YN370326 T0901317 293754-55-9

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively.

YN370212 BMS-309403 300657-03-8

BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3.

YN410053 Desfluoro-ezetimibe 302781-98-2

Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stablecholesterol absorptioninhibitor. Ezetimibe is aNiemann-Pick C1-like1 (NPC1L1)inhibitor, and is a potentNrf2activator.

YN321032 AVE 0991 304462-19-9

AVE 0991 is a nonpeptide and orally activeangiotensin-(1-7) receptoragonist with an IC50 of 21nM.

YN372548 MLN-4760 305335-31-3

MLN-4760 is a potent and selective humanACE2inhibitor (IC50, 0.44nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100μM) and bovine carboxypeptidase A (CPDA;...

YN321033 AVE 0991 sodium salt 306288-04-0

AVE 0991 sodium salt is a nonpeptide and orally activeAng-(1-7) receptor Masagonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21nM.

YN481316 MYLS22 306959-01-3

MYLS22 is a first-in-class and selectiveoptic atrophy 1 (OPA1)inhibitor. MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expres...

YN483798 Crustacean Cardioactive Pep... 309247-84-5

Crustacean Cardioactive Peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardi...

YN370237 Thrombin Inhibitor 2 312904-62-4

Thrombin Inhibitor 2 is a small molecule directthrombininhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity.