YN1570008 Capadenoson 544417-40-5

Capadenoson is a selective agonist ofadenosine-A1 receptor.

YN360129 MRS1845 544478-19-5

MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7μM. MRS1845 is anORAI1inhibitor .

YN320832 Macitentan (n-butyl analogue) 556797-16-1

Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelinETA and ETB receptorantagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and ...

YN320443 YM-254890 568580-02-9

YM-254890 is a selectiveGαq/11proteininhibitor isolated fromChromobacteriumsp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking theP2Y1signal transd...

YN330245 Avatrombopag hydrochloride 570403-17-7

Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptidethrombopoietin (TPO) receptoragonist (EC50=3.3nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases p...

YN481211 Atorvastatin acetonide 581772-29-4

Atorvastatin acetonide is an impurity of Atorvastatin, and extracted from patent WO2011131605A1, Compound 4. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipi...

YN371580 tert-Buthyl Pitavastatin 586966-54-3

tert-Buthyl Pitavastatin is the  metabolite of Pitavastatin. Pitavastatin is a potentHMG-CoAreductase inhibitor.

YN450028 SB-772077B dihydrochloride 607373-46-6

SB-772077B dihydrochloride is an aminofurazan-basedRho kinase (ROCK)inhibitor with IC50s of 5.6nM and 6nM toward ROCK1 and ROCK2, respevtively.

YN321369 Carvedilol phosphate hemihydr... 610309-89-2

Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.

YN321692 Glycerol phenylbutyrate 611168-24-2

Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from ...

YN5340004 SM 16 614749-78-9

SM 16 is aALK5/ALK4kinase inhibitor with Kis of 10 and 1.5nM, respectively.

YN320108 Vorapaxar 618385-01-6

Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

YN321312 Nelociguat 625115-52-8

Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.

YN320910 Riociguat 625115-55-1

Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.

YN360277 NF449 octasodium 627034-85-9

NF449 octasodium is a highly potentP2X1receptorantagonist, with IC50s of 0.28, 0.69, and 120nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selectiveG Proteinantagonist. NF449 octasodium suppres...

YN480638 AER-271 634913-39-6

AER-271, a phosphonate prodrug derivative of AER-270, is anaquaporin-4(AQP4) inhibitor for the research of acute ischemic stroke.

YN320087 ONO-7300243 638132-34-0

ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM.

YN320830 Cinaciguat hydrochloride 646995-35-9

Cinaciguat hydrochloride is a potent solubleguanylate cyclase(GC) activator withEC50of 15nM in platelets.

YN360594 RPR-260243 668463-35-2

RPR-260243, a potent activator ofhuman ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC50=58nM). RP...

YN290377 Kif15-IN-1 672926-32-8

Kif15-IN-1 is an inhibitor of the mitoticKinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.