YN480801 Zotarolimus 221877-54-9

Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.

YN322075 (4E)-SUN9221 222318-55-0

(4E)-SUN9221 is a potent antagonist ofα1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

YN360545 SEA0400 223104-29-8

SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. S...

YN320918 Evatanepag 223488-57-1

Evatanepag (CP-533536) is an EP2 receptor selective prostagl and in E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3nM.in vitro: CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates ...

YN360167 HMR 1556 223749-46-0

HMR 1556, a chromanol derivative, is a potentIKsblocker with IC50s of 10.5nM and 34nM in canine and guinea pig left ventricular myocytes, respectively.

YN372802 Vardenafil hydrochloride 224785-91-5

Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.

YN321292 Cinacalcet 226256-56-0

Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.

YN372544 RWJ-445167 226566-43-4

RWJ-445167 (3DP-10017) is a dual inhibitor ofthrombin and factor Xawith Kiof 4.0nM and 230nM, respectively, exhibiting potent antithrombotic activity.

YN251819 Apelin-36(rat, mouse) 230299-95-3

Apelin-36(rat, mouse) is an endogenous orphan G protein-coupled receptorAPJagonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4nM, and potently inhibits cAMP production with an EC50 of 0.52nM. Apeli...

YN371163 α-D-Glucose-1-phosphate dis... 230954-92-4

α-D-Glucose-1-phosphate disodium hydrate is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium hydrate can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiot...

YN480369 Deferitrin 239101-33-8

Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major.

YN360022 FR183998 free base 239440-20-1

FR183998 free base is a potent Na+/H+- exchangeinhibitor, with IC50s of 0.3nM, 3.1nM and 6.5nM by measurement of pH ichange in rat lymphocytes, rat and human platelets, respectively.

YN321577 Fimasartan 247257-48-3

Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

YN361073 PD0176078 248922-46-5

PD0176078 is a newly found N-typeCalcium channelblocker.

YN290036 Imiglitazar 250601-04-8

Imiglitazar (TAK559) is a potent and dual humanPPARα and PPARγ1agonist withEC50values of 67 and 31nM.

YN321857 Urotensin II (114-124), hum... 251293-28-4

Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptorGPR14.

YN1570007 Derenofylline 251945-92-3

Derenofylline (SLV320) is a selective and potent adenosine A1 antagonist with Ki of 1 nM. Derenofylline shows selective for adenosine A1 over A2A, A2B, and A3 receptors with Ki of 398 nM, 3981 nM, and 200 nM, respectively.

YN251818 Apelin-36(human) 252642-12-9

Apelin-36(human) is an endogenous orphan G protein-coupled receptorAPJagonist, with an EC50 of 20nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC50=8.61). Apelin-36 has been l...

YN290427 Ombrabulin hydrochloride 253426-24-3

Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of thetubulincytoskeleton of endothelial cells.

YN370922 Hydroxy bosentan 253688-60-7

Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities.