YN360592 ICA-121431 313254-51-2

ICA-121431 is a nanomolar potent and broad-spectrumvoltage-gated sodium channel (Nav)blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13nM and 23nM, respectively. ICA-121431 s...

YN1441176 Regadenoson 313348-27-5

Regadenoson is a selective A2A adenosine receptor agonist with coronary vasodilating activity.

YN280071 IU1 314245-33-5

IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT.

YN290301 GW0742 317318-84-6

GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ.

YN321977 Adrenomedullin (16-31), human 318480-38-5

Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the sy...

YN440327 AG-13958 319460-94-1

AG-13958 (AG-013958), a potent VEGFR tyrosine kinaseinhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD).

YN250664 Squalamine lactate 320725-47-1

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

YN360650 GlyH-101 328541-79-3

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

YN320829 Cinaciguat 329773-35-5

Cinaciguat is an activator ofguanylate cyclase (sGC), and used for acute decompensated heart failure.

YN372477 Avanafil 330784-47-9

Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.

YN370247 Betrixaban 330942-05-7

Betrixaban is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor

YN480162 Arrhythmias-Targeting Compo... 335619-12-0

Arrhythmias-Targeting Compound 1 is used in the research of arrhythmias, extracted from patent WO 2001028992 A2.

YN371003 HET0016 339068-25-6

HET0016 is a potent and selective20-hydroxyeicosatetraenoic acid (20-HETE)synthase inhibitor, with IC50 values of 17.7nM, 12.1nM and 20.6nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synt...

YN1720015 Tonapofylline 340021-17-2

Tonapofylline (BG 9928) is an orally active and selectiveadenosine A1receptorantagonist with aKiof 7.4nM for human adenosine A1receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold...

YN320312 Nebentan potassium 342005-82-7

Nebentan potassium (YM598) is a potent, selective and orally active non-peptideendothelin ETAreceptorantagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [125I] endothelin-1 binding to cloned...

YN372765 Enalaprilat D5 349554-00-3

Enalaprilat D5 (MK-422 D5) is the deuterium labeled Enalaprilat(MK-422), which is an angiotensin-converting enzyme (ACE) inhibitor.

YN372779 Enalapril D5 maleate 349554-02-5

Enalapril (MK-421) D5 maleate is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor.

YN360326 TRPM4-IN-1 351424-20-9

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channelTRPM4, with an IC50 of 1.5μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer.

YN300011 Rotigaptide 355151-12-1

Rotigaptide (ZP123) is a novel and specific modulator ofconnexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediatedgap junctioncommunication and normalizes cell-to-cell communication during acute metabolic stress. Ro...

YN370315 Darapladib 356057-34-6

Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.