YN290378 Kif15-IN-2 672926-33-9

Kif15-IN-2 is an inhibitor of the mitotickinesin Kif15, and is used for the research of cellular proliferative diseases.

YN420018 TG100-115 677297-51-7

TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.

YN1570006 Etamicastat hydrochloride 677773-32-9

Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversibledopamine-β-hydroxylase(DBH) inhibitor with an IC50 value of 107nM. Etamicastat can be used in the research of cardiovascular diseases.

YN360250 BX430 688309-70-8

BX430 is a potent and selective noncompetitive allosterichuman P2X4 receptor channelsantagonist with an IC50 of 0.54μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

YN330118 CAY 10465 688348-33-6

CAY 10465 is a selective and high-affinityAhRagonist, with a Ki of 0.2nM, and shows no effect on estrogen receptor (Ki>100000nM).

YN370176 NCX899 690655-41-5

NCX899 is a NO-releasing derivative of enalapril, and shows inhibitory activity againstangiotensin-converting enzyme (ACE)activity.

YN481189 Difluoro atorvastatin 693794-20-6

Difluoro atorvastatin (Fluoroatorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC...

YN440004 Tyrosine kinase-IN-1 705946-27-6

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2nM for KDR,Flt-1,FGFR1 and PDGFRα, respectively.

YN320687 MRS 2578 711019-86-2

MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.

YN320451 HAMI 3379 712313-35-4

HAMI 3379 is a potent and selectiveCysteinyl leukotriene (CysLT2) receptorantagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation.

YN380049 CE-245677 717899-97-3

CE-245677 is a potent reversible inhibitor ofTie2 and TrkA/Bkinases with a cellularIC50s of 4.7 and 1nM.

YN371107 VAS2870 722456-31-7

VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.

YN270604 Ivachtin 745046-84-8

Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversiblcaspase-3inhibitor with an IC50 of 23nM. Ivachtin has modest selectivity for the remaining caspases.

YN360475 Vernakalant Hydrochloride 748810-28-8

Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period.

YN321179 Atopaxar 751475-53-3

Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptorprotease-activated receptor-1 (PAR-1)antagonist. Atopaxar interferes with platelet signaling. Atopaxar can be used for the research of atherothr...

YN481743 2R,4S-Sacubitril 761373-05-1

2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

YN481742 2R,4R-Sacubitril 766480-48-2

2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

YN360474 Vernakalant 794466-70-9

Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic...

YN450128 GSK180736A 817194-38-0

GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1) ≥400-fold selec...

YN320697 Olmesartan lactone impurity 849206-43-5

Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is anangiotensin II receptor (AT1R)antagonist and has the potential for high blood pressure study.