YN360722 Mexiletine D6 hydrochloride 1329835-60-0

Mexiletine D6 hydrochloride (KOE-1173 D6 hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine hydrochloride, a Class IB antianhythmic, is a non-selective voltage-gated sodium chan...

YN480210 DS-1040 Tosylate 1335138-89-0

DS-1040 Tosylate is an orally active, selective inhibitor of activatedthrombin-activatable fibrinolysis inhibitor (TAFIa)with IC50s of 5.92nM and 8.01nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhan...

YN360045 GSK2193874 1336960-13-4

GSK2193874 is an orally active, potent, and selective blocker of transient receptor potential vanilloid 4 (TRPV4) with IC50 values of 0.04 and 0.002 μM for hTRPV4 and rTRPV4, respectively.

YN480411 Reldesemtiv 1345410-31-2

Reldesemtiv (CK-2127107) is a selective, orally active and next-generationfast skeletal muscle troponinactivator (FSTA). Reldesemtiv selectively activates fast skeletal myofibrils with an EC50of 3.4μM. Reldesemtiv increases e...

YN320365 CYM50308 1345858-76-5

CYM50308 (ML248) is a potent, selective and high affinitysphingosine-1-phosphate receptor 4 (S1P4-R)agonist with an EC50 of 56nM. CYM50308 displays 37-fold more selective forS1P4-Rthan S1P5-R. CYM50308 has no activi...

YN480898 Debutyldronedarone D6 hydroc... 1346598-70-6

Debutyldronedarone D6 hydrochloride (SR35021 D6 hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating activemetaboliteof dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a...

YN320064 Diacetolol D7 1346604-19-0

Diacetolol D7 is a deuterium labeled Diacetolol. Diacetolol is the major metabolite of Acebutolol. Diacetolol is aβ-adrenoceptorblocking and anti-arrhythmic agent.

YN320699 Olmesartan methyl ester 1347262-29-6

Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selectiveangiotensin AT1 receptorantagonist with IC50 of 66.2μM.

YN321093 Vericiguat 1350653-20-1

Vericiguat (BAY1021189, Verquvo) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.

YN360131 trans-Ned 19 1354235-96-3

trans-Ned 19, aNAADPantagonist and TPCblocker, suppresses thecalcium signalin human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations.

YN370520 Mitochonic acid 5 1354707-41-7

Mitochonic acid 5 bindsmitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulatesmitochondrial ATPsynthesis.

YN320364 CYM50260 1355026-60-6

CYM50260 is a potent and exquisitely selectivesphingosine-1-phosphate 4 receptor (S1P4-R)agonist with an EC50 of 45nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.

YN372712 Trandolaprilate D5 1356841-27-4

Tr and olaprilate D5 is a deuterium labeled Tr and olaprilate (Tr and olaprilat). Tr and olaprilate is an angiotensin-converting enzyme (ACE) inhibitor.

YN372828 Trandolapril D5 1356847-98-7

Tr and olapril D5 (RU44570 D5) is a deuterium labeled Tr and olapril (RU44570). Tr and olapril is an orally active angiotensin converting enzyme (ACE) inhibitor for hypertension and congestive heart failure (CHF).

YN372766 Enalaprilat D5 Sodium Salt 1356922-29-6

Enalaprilat (MK-422) D5 Sodium Salt is the deuterium labeled Enalaprilat(MK-422), which is an angiotensin-converting enzyme (ACE) inhibitor.

YN370560 XL-784 free base 1356992-21-6

XL-784 free base is a selectivematrix metalloproteinases (MMP)inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively.

YN321878 Atrial Natriuretic Peptide ... 1366000-58-9

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibitsend...

YN372297 Sacubitril hemicalcium salt 1369773-39-6

Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).

YN320579 Ubrogepant 1374248-77-7

Ubrogepant (MK-1602) is a novel oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine.

YN290452 ACY-775 1375466-18-4

ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5  nM.